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Table 1 Clinical manifestations and laboratory findings of HAdV infections in 150 hospitalized children with ALRTIs

From: Adenovirus infection in children with acute lower respiratory tract infections in Beijing, China, 2007 to 2012

  

Group

Variables

All cases

HAdV

HAdV/RSV

HAdV/RSV

Single infection

Dual infections

Multiple infections

(n = 150)

(n = 49)

(n = 18)

(n = 23)

Age (years)a

2.37 ± 2.89

3.68 ± 3.64

1.53 ± 2.41

1.20 ± 0.81

Male (%)

105 (70 %)

32 (65.3 %)

12 (66.7 %)

17 (73.9 %)

Symptoms and signs

    

Fever

144 (96.0 %)

48 (98.0 %)

17 (94.4 %)

23 (100 %)

T max (°C)

39.53 ± 0.68

39.73 ± 0.66

39.48 ± 0.53

39.62 ± 0.73

Duration of fever (days)

15.31 ± 13.35

18.06 ± 18.85

14.18 ± 5.86

15.17 ± 7.25

Cough

149 (99.3 %)

49 (100 %)

18 (100 %)

23 (100 %)

Rhinorrhea

24 (16.0 %)

8 (16.3 %)

2 (11.1 %)

4 (17.4 %)

Wheezing

90 (60.0 %)

25 (51.0 %)

14 (77.8 %)

17 (73.9 %)

Swelling of tonsils

44 (29.3 %)

18 (36.7 %)

2 (11.1 %)

3 (13.0 %)

Rash

15 (10.0 %)

5 (10.2 %)

7 (12.3 %)

3 (6.8 %)

Vomitting

14 (9.3 %)

5 (10.2 %)

1 (5.6 %)

4 (17.4 %)

Diarrhea

32 (21.3 %)

11 (22.4 %)

3 (16.7 %)

7 (30.4 %)

Conjunctivitis

7 (4.7 %)

2 (4.1 %)

1 (5.6 %)

0 (0 %)

Dyspnea

61 (40.7 %)

18 (36.7 %)

8 (44.4 %)

12 (52.2 %)

ICU admission

17 (11.3 %)

7 (14.3 %)

2 (11.1 %)

5 (21.7 %)

Any underlying diseases

22 (14.7 %)

10 (20.4 %)

2 (11.1 %)

2 (8.7 %)

Treatment

    

Mechanical ventilation

38 (25.3 %)

13 (26.5 %)

4 (22.2 %)

8 (34.8 %)

Coticosteriods

122 (81.3 %)

40 (81.6 %)

13 (72.2 %)

22 (95.7 %)

Inhaled Intravenous

74 (49.3 %)

22 (44.9 %)

8 (44.4 %)

14 (60.9 %)

Immunoglobulin

34 (22.7 %)

8 (16.3 %)

1 (5.6 %)

6 (26.1 %)

Length of hospital stay (days)

18.32 ± 11.31

16.19 ± 11.01

20.17 ± 10.22

20.52 ± 10.44

Laboratory findings

    

WBC (×109/L)

10.09 ± 4.61

9.34 ± 4.85

10.50 ± 3.79

9.86 ± 4.26

CRP (mg/L)

31.64 ± 35.93

36.01 ± 39.67

36.78 ± 30.25

32.42 ± 43.52

AST, median (IQR) (U/L)

33 (45–71.5)

45 (34–81.8)

38.5 (33–56.3)

57 (33–83)

ALT, median (IQR) (U/L)

21 (16–36)

18.1 (15–33)

21 (18–36.5)

22 (19–46)

LDH, median (IQR) (U/L)

360 (262.5-668.5)

369.5 (285.7-899.5)

326.5 (260–584.5)

439 (288–747)

CK, median (IQR) (U/L)

83 (45–192)

87.5 (46.8-264)

84 (42.5-221.8)

88 (38–137)

HBDH, median (IQR) (U/L)

274 (200.5-508.5)

275 (203.3-562.3)

258 (203–447.9)

355 (221.5–524)

  1. ICU intensive care unit, WBC white blood cell, CRP C-reaction protein, AST aspartate aminotransferase, ALT alanine aminotransferase, LDH, lactate dehydrogenase, CK creatinine kinase, HBDH hydroxybutyrate dehydrogenase, IQR interquartile range
  2. aone way ANOVA: single infection vs dual infections vs multiple infections, p = 0.001