Characteristics | Subgroups | N Studies | Unadjusted OR | Results: 95Â % CI | I 2 | Cochran Q |
---|---|---|---|---|---|---|
p-value | ||||||
Main analysis | All patients | 39 | 0.38 | 0.30, 0.47 | 64.9Â % | <0.001 |
Non-Acinetobacter | Excluding Acinetobacter spp studies | 24 | 0.46 | 0.34, 0.60 | 61.4Â % | <0.001 |
Mortality outcome time point | 14-day | 12 | 0.40 | 0.29, 0.55 | 44Â % | 0.05 |
30-day | 21 | 0.35 | 0.25, 0.48 | 68.5Â % | <0.001 | |
In-hospital (time NR) | 8 | 0.51 | 0.30, 0.85 | 70.6Â % | 0.001 | |
Pathogen | Acinetobacter | 15 | 0.29 | 0.21, 0.39 | 51.9Â % | 0.01 |
Gram-negative | 6 | 0.27 | 0.13, 0.53 | 81.1Â % | <0.001 | |
ESBL E. coli | 4 | 0.66 | 0.35, 1.22 | 18.7Â % | 0.30 | |
Klebsiella | 3 | 1.00 | 0.57, 1.78 | 16.6Â % | 0.30 | |
pseudomonas | 11 | 0.41 | 0.29, 0.60 | 45.0Â % | 0.05 | |
Pathogen and source of infection | ESBL BSI | 6 | 0.71 | 0.38, 1.31 | 48.1Â % | 0.086 |
Klebsiella BSI | 2 | 0.74 | 0.37, 1.46 | 0.0Â % | 0.453 | |
A Pneumonia | 2 | 0.24 | 0.14, 0.40 | 0.0Â % | 0.466 | |
A BSI | 13 | 0.30 | 0.21, 0.43 | 57.4Â % | 0.005 | |
P. pneumonia | 2 | 0.58 | 0.18, 1.89 | 77.4Â % | 0.036 | |
P BSI | 9 | 0.38 | 0.26, 0.56 | 35.6Â % | 0.133 | |
Gram-negative BSI | 4 | 0.33 | 0.16, 0.70 | 83.7Â % | <.0001 | |
Gram-negative pneumonia | 1 | 0.09 | 0.03, 0.30 | NA | NA | |
ICU-related infections by included subjects | ≤50% | 12 | 0.413 | 0.30, 0.57 | 40.5 % | <0.001 |
>50% | 23 | 0.38 | 0.27, 0.53 | 68.9Â % | 0.07 | |
Not reported | 4 | 0.27 | 0.11, 0.67 | 83.2Â % | <0.001 | |
AAT timeliness with regard to initial culture | ≤24 h | 11 | 0.50 | 0.35, 0.71 | 50.1 % | 0.024 |
≤48 h | 9 | 0.40 | 0.22, 0.72 | 78.8 % | <0.001 | |
≤72 h | 7 | 0.29 | 0.22, 0.39 | 0.0 % | 0.73 | |
Timeliness NR | 10 | 0.32 | 0.20, 0.52 | 66.2Â % | 0.001 | |
Definitions of AAT | Timeliness and susceptibility | 26 | 0.37 | 0.28, 0.49 | 68.3Â % | <0.001 |
Timeliness alone | 3 | 0.56 | 0.25, 1.23 | 35.4Â % | 0.213 | |
Susceptibility alone | 8 | 0.36 | 0.23, 0.55 | 50.0Â % | 0.051 | |
Not reported | 2 | 0.31 | 0.03, 3.61 | 90.1Â % | 0.001 |