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Table 1 Subgroup analyses of unadjusted mortality in hospitalized patients receiving AAT

From: Appropriate initial antibiotic therapy in hospitalized patients with gram-negative infections: systematic review and meta-analysis

Characteristics Subgroups N Studies Unadjusted OR Results: 95 % CI I 2 Cochran Q
p-value
Main analysis All patients 39 0.38 0.30, 0.47 64.9 % <0.001
Non-Acinetobacter Excluding Acinetobacter spp studies 24 0.46 0.34, 0.60 61.4 % <0.001
Mortality outcome time point 14-day 12 0.40 0.29, 0.55 44 % 0.05
30-day 21 0.35 0.25, 0.48 68.5 % <0.001
In-hospital (time NR) 8 0.51 0.30, 0.85 70.6 % 0.001
Pathogen Acinetobacter 15 0.29 0.21, 0.39 51.9 % 0.01
Gram-negative 6 0.27 0.13, 0.53 81.1 % <0.001
ESBL E. coli 4 0.66 0.35, 1.22 18.7 % 0.30
Klebsiella 3 1.00 0.57, 1.78 16.6 % 0.30
pseudomonas 11 0.41 0.29, 0.60 45.0 % 0.05
Pathogen and source of infection ESBL BSI 6 0.71 0.38, 1.31 48.1 % 0.086
Klebsiella BSI 2 0.74 0.37, 1.46 0.0 % 0.453
A Pneumonia 2 0.24 0.14, 0.40 0.0 % 0.466
A BSI 13 0.30 0.21, 0.43 57.4 % 0.005
P. pneumonia 2 0.58 0.18, 1.89 77.4 % 0.036
P BSI 9 0.38 0.26, 0.56 35.6 % 0.133
Gram-negative BSI 4 0.33 0.16, 0.70 83.7 % <.0001
Gram-negative pneumonia 1 0.09 0.03, 0.30 NA NA
ICU-related infections by included subjects ≤50% 12 0.413 0.30, 0.57 40.5 % <0.001
>50% 23 0.38 0.27, 0.53 68.9 % 0.07
Not reported 4 0.27 0.11, 0.67 83.2 % <0.001
AAT timeliness with regard to initial culture ≤24 h 11 0.50 0.35, 0.71 50.1 % 0.024
≤48 h 9 0.40 0.22, 0.72 78.8 % <0.001
≤72 h 7 0.29 0.22, 0.39 0.0 % 0.73
Timeliness NR 10 0.32 0.20, 0.52 66.2 % 0.001
Definitions of AAT Timeliness and susceptibility 26 0.37 0.28, 0.49 68.3 % <0.001
Timeliness alone 3 0.56 0.25, 1.23 35.4 % 0.213
Susceptibility alone 8 0.36 0.23, 0.55 50.0 % 0.051
Not reported 2 0.31 0.03, 3.61 90.1 % 0.001
  1. A Acinetobacter, AAT Appropriate initial antibacterial therapy, BSI Blood stream infection, CI Confidence Interval, E.coli Escherichia coli, ESBL Extended spectrum beta-lactamase, hr hour, ICU Intensive care unit, OR Odds ratio, P Pseudomonas, N Number, NR Not reported