Research opportunities | Research questions |
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Retrospective analysis of global PID registries | - What are the survival prospects of individuals in different PID categories in different income levels (particularly CVIDs) and how are they changing over time? |
- How does IVIG treatment affect PID survival? | |
Expanded and longitudinal screening of PID patients for poliovirus (with reporting of IVIG treatment status for screened PID patients) | - What fraction of patients with different PIDs (CVID, SCID, others) will develop prolonged and chronic excretion if infected with OPV? |
- How many prolonged and chronic excretors currently exist globally? | |
- How does IVIG treatment affect the probability of developing a long-term infection if infected with OPV? | |
Clinical trials with PAVDs involving long-term excretors | - How effective are individual and combined PAVDs in clearing poliovirus infections? |
Systematic detailed reporting of timelines of events for all known long-term excretors | - Does a PID patient who spontaneously recovered from a long-term infection develop sufficient immunity to prevent future long-term infections of the same or other serotypes? |
- How does IVIG treatment affect the probability of developing a long-term infection if infected with OPV? | |
- What is the current survival and excretion status and the estimated time of infection, recovery (if applicable) and death (if applicable) for each known long-term excretor? | |
Continued follow-up of all identified long term excretors (including after spontaneous recovery from infection ) | - Does a PID patient who spontaneously recovers from a long-term infection develop sufficient immunity to prevent future long-term infections of the same or other serotypes? |
- Do frequent concurrent enteric infections result in an increased probability of spontaneous recovery from long-term poliovirus infections? | |
Intensification of searches for PID patients causing apparent iVDPVs isolated from the environment | - Who are the sources of apparent iVDPVs isolated from the environment? |
- What are the bounds on current chronic excretor prevalence in countries that stopped using OPV? | |
Expanded environmental surveillance for apparent iVDPVs | - What are the bounds on current chronic excretor prevalence? |
- Can iVDPVs transmit widely? | |
Modeling of iVDPV introductions into the general population after OPV cessation | - What are the expected consequences of prolonged and chronic excretion beyond OPV cessation? |
Expanded stool sampling around known long-term excretors | - Are iVDPVs as transmissible as cVDPVs and WPVs? |