Health and economic consequences of different options for timing the coordinated global cessation of the three oral poliovirus vaccine serotypes

Table 1 OPV cessation timing options considered

Name of OPV cessation timing option	OPV1 cessation	OPV2 cessation	OPV3 cessation	Addition of IPV dose(s)^a	RI vaccine^b	SIA vaccine(s)^c
Current timing plan	April 1, 2019	April 1, 2016	April 1, 2019	January 1, 2015	tOPV before OPV2 cessation, then bOPV until OPV13 cessation	tOPV and bOPV before OPV2 cessation, then only bOPV until OPV13 cessation
OPV23 cessation in 2017	April 1, 2019	April 1, 2017	April 1, 2017	January 1, 2015	tOPV before OPV23 cessation, then mOPV1 until OPV1 cessation	tOPV and bOPV before OPV23 cessation, then only mOPV1 until OPV1 cessation
OPV123 cessation in 2018	April 1, 2018	April 1, 2018	April 1, 2018	January 1, 2015	tOPV until all-OPV cessation	tOPV and bOPV until OPV123 cessation
OPV123 cessation in 2019	April 1, 2019	April 1, 2019	April 1, 2019	January 1, 2015	tOPV until all-OPV cessation	tOPV and bOPV until OPV123 cessation
OPV123 cessation in 2019 with tOPV-only from 2017	April 1, 2019	April 1, 2019	April 1, 2019	January 1, 2015	tOPV until all-OPV cessation	tOPV and bOPV until April 1, 2017, then only tOPV until OPV123 cessation
OPV123 cessation in 2019 with IPV added from 2018	April 1, 2019	April 1, 2019	April 1, 2019	January 1, 2018	tOPV until all-OPV cessation	tOPV and bOPV until OPV123 cessation

Abbreviations: bOPV, bivalent OPV (serotypes 1 and 3); IPV, inactivated poliovirus vaccine; mOPV1, serotype 1 monovalent OPV; OPV, oral poliovirus vaccine; OPV(##) cessation, globally-coordinated cessation of OPV containing the serotype(s) indicated by ##; RI, routine immunization; SIA, supplemental immunization activity; tOPV, trivalent OPV
^aAssumes IPV co-administered with third non-birth OPV RI dose from time of addition of IPV dose until cessation of the last OPV serotype, followed by a single-IPV-dose schedule for low- and lower middle-income blocks; assumes a sequential IPV/IPV/OPV/OPV schedule from time of addition of IPV doses until cessation of the last OPV serotypes followed by IPV/IPV/IPV schedule in upper middle-income blocks that use OPV-only in 2013; assumes a sequential IPV/IPV/OPV/OPV schedule from the beginning of the analytical time horizon until cessation of the last OPV serotypes followed by an IPV/IPV/IPV schedule in upper middle- and high-income blocks that already use IPV/OPV in 2013; assumes an IPV/IPV/IPV schedule for all years in high-income countries that already use IPV-only in 2013 [34]
^bIn blocks that use OPV or IPV/OPV for RI in 2013
^cIn blocks that use OPV or IPV/OPV in 2013 and require SIAs, not including any mOPV used for outbreak response SIAs that override any planned, preventive SIAs [34]

ISSN: 1471-2334