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Table 7 Expected global vaccination costs, paralytic cases, and incremental net benefits in 2013 United States dollars ($) for various policy options and alternative assumptions, compared to the reference case without SIAs (i.e., policy RC no SIA)

From: An economic analysis of poliovirus risk management policy options for 2013–2052

Global minimum policy

Number of iterations with OPV restart

Expected vaccination costs ($ billions)

Expected paralytic polio cases

Expected incremental net benefits ($ billions)

IPV5

2

37

6,500

16

IPV10

2

38

6,200

15

IPV through Tend

10

42

21,000

10

No IPV

6

37

23,000

15

Variations on IPV5

    

IPV5, PAVD40%

2

37

6,500

16

IPV5, PAVD90%

1

36

2,300

16

No tOPV intensification prior to OPV2 cessation

3

37

9,200

16

Doubled frequency of exportations

5

38

29,000

14

Threshold for OPV restart

    

 - 15,000 cumulative cases

2

37

6,500

16

 - 10,000 cumulative cases

3

37

12,000

16

 - 5,000 cumulative cases

4

37

16,000

16

 - 1,000 cumulative cases

8

37

48,000

15

  1. Abbreviations(see Table1for policy abbreviations): IPV, inactivated poliovirus vaccine; OPV, oral poliovirus vaccine; PAVD (40 %,90 %), polio antiviral drug (passive or active use, respectively); RC, reference case; SIA, supplemental immunization activity; Tend, end of analytical time horizon (i.e., December 31, 2052); tOPV, trivalent OPV