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Table 1 Virucidal activity of 4 different PVP-I preparations against MVA

From: Povidone-iodine hand wash and hand rub products demonstrated excellent in vitro virucidal efficacy against Ebola virus and modified vaccinia virus Ankara, the new European test virus for enveloped viruses

Test product Dilution Log10 reduction factor (95 % confidence interval, where applicable)
Clean conditions Dirty conditions
Application time Application time
15 s 30 s 60 s 15 s 30 s 60 s
PVP-I solution (10 g/L available iodine) Undiluted (10 g/L) ≥4.00 ≥4.00 ≥4.00 ≥4.17 ≥4.17 ≥4.17
1:10 (1 g/L) ≥5.67 ≥5.67 ≥5.67 ≥5.50 ≥5.50 ≥5.50
1:100 (0.1 g/L) 4.33 (±0.63) 5.67 (±0.60) ≥6.33 2.83 (±0.54) 3.50 (±0.65) 3.50 (±0.54)
PVP-I surgical scrub (7.5 g/L available iodine) Undiluted (7.5 g/L) ≥4.00 ≥4.00 ≥4.00 ≥4.17 ≥4.17 ≥4.17
1:10 (0.75 g/L) ≥5.50 ≥5.50 ≥5.50 ≥5.67 ≥5.67 ≥5.67
1:100 (0.075 g/L) 3.83 (±0.65) 4.17 (±0.58) 4.50 (±0.58) 1.00 (±0.70) 1.67 (±0.70) 1.83 (±0.71)
PVP-I skin cleanser (4 g/L available iodine) Undiluted (4 g/L) ≥4.17 ≥4.17 ≥4.17 ≥4.00 ≥4.00 ≥4.00
1:10 (0.4 g/L) 4.50 (±0.54) ≥4.67 ≥4.67 4.33 (±0.56) ≥4.50 ≥4.50
1:100 (0.04 g/L) 3.33 (±0.56) 3.67 (±0.47) 3.67 (±0.47) 0.33 (±0.56) 1.00 (±0.63) 1.00 (±0.63)
PVP-I/alcohol solution (3.2 g/L available iodine) Undiluted (3.2 g/L) ≥5.67 ≥5.67 ≥5.67 ≥5.67 ≥5.67 ≥5.67
1:10 (0.32 g/L) 5.50 (±0.54) 6.33 (±0.56) 6.33 (±0.56) 3.00 (±0.63) 4.00 (±0.47) 4.83 (±0.33)
1:100 (0.032 g/L) 1.83 (±0.54) 2.00 (±0.60) 2.50 (±0.54) −0.17 (±0.68) 0.00 (±0.60) 0.17 (±0.54)
  1. Clean conditions: 0.3 g/L bovine serum albumin (BSA); dirty conditions: 3.0 g/L BSA + 3.0 mL/L erythrocytes. Results in bold indicate virucidal activity (≥4 log10 reduction in viral titre)