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Table 5 Penicillin-binding protein 2 (PBP 2) [7] and porB gene sequence cluster (A1-D) in Neisseria gonorrhoeae isolates (n = 149) cultured from 1998 to 2005 (only isolates with resistance or decreased susceptibility to cefixime in 2002–2005) in Kanagawa area, Japan

From: Emergence and evolution of internationally disseminated cephalosporin-resistant Neisseria gonorrhoeae clones from 1995 to 2005 in Japan

PBP 2 (2003–2005, n = 76a)

A1

A2

A3

B1

B2

C

D

X

X (62)

41

9

0

4

4

2

2

+ E101D (XXIV) (1)

   

1

   

+ A501V (XXX) (2)

2

      

XXXIV

XXXIV (1)

   

1

   

+ P551L (XXXII) (2)

   

2

   

+ P551Q (1)

   

1

   

-

XXVI (6)

6

      

PBP 2 (1998–2002, n = 73b)

A1

A2

A3

B1

B2

C

D

X

X (67)

33

3

2

1

27

1

0

+ A532V (XXXI) (1)

    

1

  

XXXIV

XXXIV (2)

   

2

   

+ A486V (1)

   

1

   
  1. aOne isolate possessed the non-mosaic PBP 2 XIII [7]. The porB sequence from this isolate belonged to the cluster A2
  2. bTwo isolates possessed the non-mosaic PBP 2 VII and XI [7]