Table 1 Characteristics of the patients according to the multi-drug resistant organisms (MDRO) carrier status
From: First multicenter study on multidrug resistant bacteria carriage in Chinese ICUs
Characteristic | Total | Type of MDRO carriage | |||
|---|---|---|---|---|---|
patients | On admission | ICU-acquired | Not carrier | P value* | |
n (%) | n (%) | n (%) | n (%) | ||
Total | 686 (100.0) | 247 (100.0) | 104 (100.0) | 335 (100.0) | |
Male (yes) | 405 (59.0) | 149 (60.3) | 63 (60.6) | 193 (57.6) | 0.59 |
Severe/critical status on admission | 525 (75.5) | 192 (77.7) | 87 (83.7) | 246 (73.4) | 0.04 |
Previous hospitalization | 190 (27.7) | 121 (49.0) | 46 (44.2) | 125 (37.3) | 0.21 |
Origin of patients before ICUa | |||||
- community | 28 (4.1) | 12 (4.9) | 5 (4.8) | 11 (3.3) | reference |
- emergency room | 115 (16.8) | 40 (16.2) | 30 (28.9) | 45 (13.4) | 1.0 |
- other wards | 494 (72.0) | 173 (70.0) | 61 (58.7) | 260 (77.6) | 0.21 |
- other hospitals | 30 (4.4) | 13 (5.2) | 6 (5.8) | 11 (3.3) | 0.58 |
- others/ no data | 16 (2.3) | 7 (2.8) | 2 (1.9) | 7 (2.1) | 1.0 |
Invasive devices before ICU | 313 (45.6) | 132 (53.4) | 48 (46.2) | 133 (39.7) | 0.24 |
Invasive devices in ICU | 640 (93.3) | 233 (94.3) | 102 (98.1) | 305 (91.0) | 0.02 |
- mechanical ventilation | 381 (55.5) | 135 (54.7) | 66 (63.5) | 180 (53.7) | 0.08 |
- indwelling urinary catheter | 629 (91.7) | 224 (90.7) | 98 (94.2) | 307 (91.6) | 0.39 |
- intravascular catheter | 514 (74.9) | 200 (81.0) | 88 (84.6) | 226 (67.5) | 0.001 |
Antibiotic in the last 3 months | 279 (40.7) | 118 (47.8) | 58 (55.8) | 103 (30.7) | <0.001 |
Antibiotic on ICU admission | 586 (85.6) | 204 (82.6) | 89 (85.6) | 293 (87.7) | 0.57 |
- > 1 drug | 232 (33.8) | 82 (33.2) | 39 (37.5) | 111 (33.1) | 0.41 |
Antibiotic in ICU | |||||
- none | 37 (5.4) | 17 (6.9) | 5 (4.8) | 15 (4.5) | reference |
- 1 drug | 314 (45.8) | 107 (43.3) | 33 (31.7) | 174 (51.9) | 0.34 |
- 2 drugs | 210 (30.6) | 69 (27.9) | 28 (26.9) | 113 (33.7) | 0.56 |
- > 2 drugs (3–7) | 125 (18.2) | 54 (21.9) | 38 (36.6) | 33 (9.9) | 0.04 |
- penicillins | 8 (1.2) | 3 (1.2) | 0 | 5 (1.5) | 0.60 |
- penicillins + inhibitors | 192 (28.0) | 72 (29.2) | 46 (44.2) | 74 (22.1) | <0.001 |
- cephalosporins 1st & 2nd G | 155 (22.6) | 51 (20.7) | 13 (12.5) | 91 (27.2) | 0.002 |
- cephalosporins 3rd G /aztreonam | 223 (32.5) | 79 (32.0) | 40 (38.5) | 104 (31.0) | 0.16 |
- carbapenems | 140 (20.4) | 61 (24.7) | 30 (29.9) | 49 (14.6) | 0.001 |
- aminoglycosides | 13 (1.9) | 4 (1.6) | 4 (3.9) | 5 (1.5) | 0.23 |
- fluoroquinolones | 111 (16.2) | 45 (18.2) | 15 (14.4) | 51 (15.2) | 0.84 |
- glycopeptides | 116 (16.9) | 45 (18.2) | 33 (31.7) | 38 (11.3) | <0.001 |
- others | 194 (28.3) | 69 (27.9) | 32 (30.8) | 93 (27.8) | 0.55 |
Type of discharge at 28 ICU daysb | |||||
- discharged from hospital | 83 (12.1) | 35 (14.2) | 16 (15.4) | 32 (9.6) | reference |
- remain in ICU | 36 (5.2) | 16 (6.5) | 16 (15.4) | 4 (1.2) | 0.001 |
- other ward | 516 (75.2) | 173 (70.0) | 58 (55.8) | 285 (85.3) | 0.01 |
- death | 45 (6.6) | 22 (8.9) | 10 (9.6) | 13 (3.9) | 0.44 |
Median (range) | Median (range) | Median (range) | Median (range) | ||
Age (year) | 66 (9–101) | 65 (9–101) | 66 (21–95) | 67 (15–94) | 0.99 |
Length of stay (days) | |||||
- in hospital before ICU admission | 6 (0 – >60) | 7 (0 – >60) | 4 (0 – >60) | 7 (0 – >60) | 0.05 |
- in ICU | 4 (4 – >28) | 4 (1 – >28) | 10 (2 – >28) | 4 (1 – >28) | <0.001 |
- before MDR acquisition | 7 (3 – >28) | 0 | 7 (3 – >28) | - | |
Total antibiotic-days in ICU | 3 (0 –27) | 5 (0–21) | 3 (0–25) | <0.001 | |