Table 1 Performance of proadrenomedullin, copeptin, C-reactive protein, white blood cell and band neutrophils (band cells) counts, for predicting “complicated” (with empyema or bacteremia) and “bacteremic“community-acquired pneumonia
From: Proadrenomedullin and copeptin in pediatric pneumonia: a prospective diagnostic accuracy study
Complicated CAP (n = 11; 12.5 %) vs. non-complicated CAP (n = 77) | |||||
N = 88 | Proadrenomedullin >0.16 nmol/L | Copeptin >10 pmol/L | CRP >100 mg/L | White blood cells >15G/L | Band cells >1.5G/L |
Sensitivity % | 72.7 (39.0–94.0) | 45.5 (16.7–76.6) | 100.0 (71.5–100) | 72.7 (39.0–94.0) | 90.9 (58.7–99.8) |
Specificity % | 71.4 (60.0–81.2) | 68.8 (57.3–78.9) | 77.0 (65.8–86.0) | 58.7 (46.7–69.9) | 75.7 (64.3–84.9) |
LR+ | 2.55 (1.5–4.2) | 1.46 (0.70–3.0) | 4.11 (2.68–6.29) | 1.76 (1.12–2.76) | 3.55 (2.26–5.56) |
LR- | 0.38 (0.1–1.0) | 0.79 (0.45–1.39) | 0.05 (0.00–0.82) | 0.46 (0.17–1.24) | 0.17 (0.04–0.75) |
PPV% | 26.7 (12.3–45.9) | 17.2 (5.8–35.8) | 39.3 (21.5–59.4) | 20.5 (9.3–36.5) | 35.7 (18.6–55.9) |
NPV% | 94.8 (85.6–98.9) | 89.8 (79.2–96.2) | 100.0 (93.7–100) | 93.6 (82.5–98.7) | 98.2 (90.6–100) |
ROC area | 0.72 (0.6–0.9) | 0.57 (0.41–0.73) | 0.89 (0.84–0.93) | 0.66 (0.51–0.81) | 0.83 (0.73–0.93) |
Odds ratioa | 6.67 (1.7–25.3) | 1.84 (0.54–6.30) | 75.6 (4.2–1348) | 3.78 (1.00–14.2) | 21.4 (3.57–128) |
Bacteremic CAP (n = 4; 4.5 %) vs. non-bacteremic CAP (n = 84) | |||||
N = 88 | Proadrenomedullin >0.16 nmol/L | Copeptin >10 pmol/L | CRP >100 mg/L | White blood cells >15G/L | Band cells >1.5G/L |
Sensitivity % | 100 (39.8–100.0) | 50.0 (6.8–93.2) | 100 (39.8–100) | 75.0 (19.4–99.4) | 75.0 (19.4–99.4) |
Specificity % | 70.0 (58.7–79.7) | 67.5 (56.1–77.6) | 70.5 (59.1–80.3) | 57.0 (45.3–68.1) | 71.8 (60.5–81.4) |
LR+ | 2.98 (1.91–4.63) | 1.54 (0.55–4.31) | 3.03 (1.93–4.73) | 1.62 (0.87–3.04) | 2.46 (1.26–4.81) |
LR- | 0.14 (0.01–2.00) | 0.74 (0.27–2.00) | 0.14 (0.01–1.98) | 0.53 (0.14–2.04) | 0.42 (0.11–1.61) |
PPV % | 14.3 (4.0–32.7) | 7.1 (0.9–23.5) | 14.8 (4.2–33.7) | 8.1 (1.7–21.9) | 12.0 (2.5–31.2) |
NPV % | 100.0 (93.6–100.0) | 96.4 (87.7–99.6) | 100 (93.5–100) | 97.8 (88.5–99.9) | 98.2 (90.6–100) |
ROC area | 0.85 (0.80–0.90) | 0.59 (0.30–0.88) | 0.85 (0.80–0.90) | 0.66 (0.41–0.91) | 0.73 (0.48–0.98) |
Odds ratioa | 20.8 (1.1–400.5) | 2.08 (0.35–12.5) | 21.3 (1.1–411) | 3.08 (0.43–21.9) | 5.86 (0.81–42.2) |