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Table 4 Gene expression in the eight C. parapsilosis isolates cultured in the presence of fluconazole with concentrations of 1/2 MIC

From: Development of fluconazole resistance in a series of Candida parapsilosis isolates from a persistent candidemia patient with prolonged antifungal therapy

Sample MDR1 b MRR1 b CDR1 b ERG11 b UPC2 b
Expression Expression SEM Expression Expression SEM Expression Expression SEM Expression Expression SEM Expression Expression SEM
ATCC22019a 1.00 0.04 1.00 0.03 1.00 0.02 1.00 0.04 1.00 0.03
PU017 2.38 0.09 1.74 0.04 0.81 0.03 0.87 0.02 1.04 0.03
PU116 2.33 0.13 1.55 0.10 1.03 0.06 1.08 0.06 1.16 0.06
PU123 9.70 0.63 3.90 0.20 0.21 0.01 0.26 0.15 0.31 0.02
PU127 9.01 0.28 3.99 0.14 0.28 0.01 0.35 0.01 0.37 0.02
PU090 2.16 0.10 0.74 0.03 0.77 0.03 0.55 0.03 0.53 0.02
PU106 1.45 0.07 1.55 0.05 1.55 0.04 1.13 0.05 1.86 0.07
PU131 1.17 0.04 1.31 0.05 0.95 0.02 0.52 0.01 0.52 0.02
  1. aATCC22019 isolates was used as control isolate, and was also cultured in the presence of 1/2 MIC of fluconazole
  2. bAll the samples for each gene were tested in triplicate. The left column shows the mean value of expression, and the right column shows the Standard Error of Mean (SEM)