Table 5 Variation in msp1 block 2 diversity with age, altitude, antimalarial usage and season in individuals with Uncomplicated Malaria (UM) and Asymptomatic Parasitaemia (AP); a, b, c, d, e significance of differences in K1, MAD20, RO33, polyclonaility and MR proportions in uncomplicated and asymptomatic parasitaemia individuals respectively
Parameter | Uncomplicated Malaria [n (%)] | Asymptomatic parasitaemia [n (%)] | P value | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
a | b | c | d | e | |||||||||||
K1 | MAD20 | RO33 | Polyclonality | MR | K1 | MAD20 | RO33 | Polyclonality | MR | ||||||
Age group (years) | |||||||||||||||
< 5 | 11 (65) | 14 (82) | 9 (53) | 12 (71) | 11 (65) | 16 (94) | 7 (41) | 7 (41) | 10 (59) | 3 (18) | 0.043 | 0.013 | 0.300 | 0.473 | 0.005 |
5 – 9 | 11 (69) | 7 (44) | 5 (31) | 6 (38) | 4 (25) | 25 (89) | 16 (57) | 16 (57) | 17 (61) | 12 (43) | 0.100 | 0.392 | 0.447 | 0.138 | 0.236 |
10 -14 | 8 (73) | 4 (36) | 4 (36) | 4 (36) | 5 (46) | 7 (100) | 6 (86) | 6 (86) | 6 (86) | 4 (57) | 0.202 | 0.057 | 0.352 | 0.057 | 0.500 |
≥ 15 | 27 (75) | 20 (56) | 19 (53) | 24 (67) | 17 (47) | 7 (78) | 3 (33) | 4 (44) | 4 (44) | 2 (22) | 0.618 | 0.207 | 0.470 | 0.198 | 0.164 |
P value | 0.882 | 0.058 | 0.423 | 0.070 | 0.154 | 0.450 | 0.136 | 0.804 | 0.414 | 0.158 | |||||
Altitude | |||||||||||||||
Low | 14 (78) | 13 (72) | 7 (39) | 11 (61) | 6 (33) | 10 (91) | 3 (27) | 4 (36) | 5 (46) | 3 (27) | 0.356 | 0.023 | 0.604 | 0.330 | 0.534 |
Intermediate | 28 (65) | 20 (47) | 23 (54) | 22 (51) | 24 (56) | 30 (91) | 17 (52) | 10 (30) | 16 (55) | 8 (24) | 0.009 | 0.665 | 0.043 | 0.770 | 0.006 |
High | 16 (80) | 12 (60) | 8 (40) | 14 (70) | 8 (40) | 15 (88) | 12 (71) | 12 (71) | 14 (82) | 10 (59) | 0.413 | 0.501 | 0.063 | 0.315 | 0.254 |
P value | 0.383 | 0.165 | 0.450 | 0.354 | 0.214 | 0.952 | 0.080 | 0.022 | 0.085 | 0.044 | |||||
Season | |||||||||||||||
Transitiona | 11 (85) | 8 (62) | 5 (39) | 8 (62) | 4 (31) | 16 (94) | 11 (65) | 11 (65) | 13 (77) | 9 (53) | 0.397 | 0.579 | 0.153 | 0.314 | 0.225 |
Rainy | 47 (69) | 37 (54) | 33 (49) | 39 (57) | 34 (50) | 39 (89) | 21 (48) | 15 (34) | 24 (55) | 12 (27) | 0.017 | 0.489 | 0.132 | 0.770 | 0.017 |
P value | 0.217 | 0.636 | 0.505 | 0.779 | 0.203 | 0.460 | 0.183 | 0.030 | 0.116 | 0.059 | |||||
Reported Antimalarial use | |||||||||||||||
Yes | 12 (67) | 7 (39) | 11 (52) | 7 (39) | 8 (44) | 3 (100) | 2 (67) | 1 (33) | 2 (67) | 1 (33) | 0.342 | 0.388 | 0.684 | 0.388 | 0.612 |
No | 15 (71) | 15 (71) | 7 (39) | 15 (71) | 9 (43) | 38 (91) | 25 (60) | 21 (50) | 28 (67) | 19 (45) | 0.059 | 0.355 | 0.859 | 0.702 | 0.858 |
P value | 0.748 | 0.041 | 0.399 | 0.041 | 0.921 | 0.751 | 0.651 | 0.517 | 0.746 | 0.585 | |||||
Level of parasitaemia (parasites/μl) | |||||||||||||||
< 10, 000 | 25 (78) | 22 (69) | 11 (34) | 20 (63) | 14 (44) | 43 (92) | 27 (57) | 20 (43) | 30 (64) | 18 (38) | 0.089 | 0.310 | 0.465 | 0.904 | 0.628 |
≥ 10, 000 | 33 (67) | 23 (47) | 27 (55) | 27 (55) | 24 (49) | 12 (86) | 5 (36) | 6 (43) | 7 (50) | 3 (21) | 0.157 | 0.456 | 0.418 | 0.736 | 0.066 |
P value | 0.293 | 0.053 | 0.068 | 0.510 | 0.645 | 0.420 | 0.153 | 0.610 | 0.352 | 0.201 | |||||