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Table 5 Variation in msp1 block 2 diversity with age, altitude, antimalarial usage and season in individuals with Uncomplicated Malaria (UM) and Asymptomatic Parasitaemia (AP); a, b, c, d, e significance of differences in K1, MAD20, RO33, polyclonaility and MR proportions in uncomplicated and asymptomatic parasitaemia individuals respectively

From: Plasmodium falciparum merozoite surface protein 1 block 2 gene polymorphism in field isolates along the slope of mount Cameroon: a cross – sectional study

Parameter Uncomplicated Malaria [n (%)] Asymptomatic parasitaemia [n (%)] P value
a b c d e
K1 MAD20 RO33 Polyclonality MR K1 MAD20 RO33 Polyclonality MR
Age group (years)
< 5 11 (65) 14 (82) 9 (53) 12 (71) 11 (65) 16 (94) 7 (41) 7 (41) 10 (59) 3 (18) 0.043 0.013 0.300 0.473 0.005
5 – 9 11 (69) 7 (44) 5 (31) 6 (38) 4 (25) 25 (89) 16 (57) 16 (57) 17 (61) 12 (43) 0.100 0.392 0.447 0.138 0.236
10 -14 8 (73) 4 (36) 4 (36) 4 (36) 5 (46) 7 (100) 6 (86) 6 (86) 6 (86) 4 (57) 0.202 0.057 0.352 0.057 0.500
≥ 15 27 (75) 20 (56) 19 (53) 24 (67) 17 (47) 7 (78) 3 (33) 4 (44) 4 (44) 2 (22) 0.618 0.207 0.470 0.198 0.164
P value 0.882 0.058 0.423 0.070 0.154 0.450 0.136 0.804 0.414 0.158      
Altitude
Low 14 (78) 13 (72) 7 (39) 11 (61) 6 (33) 10 (91) 3 (27) 4 (36) 5 (46) 3 (27) 0.356 0.023 0.604 0.330 0.534
Intermediate 28 (65) 20 (47) 23 (54) 22 (51) 24 (56) 30 (91) 17 (52) 10 (30) 16 (55) 8 (24) 0.009 0.665 0.043 0.770 0.006
High 16 (80) 12 (60) 8 (40) 14 (70) 8 (40) 15 (88) 12 (71) 12 (71) 14 (82) 10 (59) 0.413 0.501 0.063 0.315 0.254
P value 0.383 0.165 0.450 0.354 0.214 0.952 0.080 0.022 0.085 0.044      
Season
Transitiona 11 (85) 8 (62) 5 (39) 8 (62) 4 (31) 16 (94) 11 (65) 11 (65) 13 (77) 9 (53) 0.397 0.579 0.153 0.314 0.225
Rainy 47 (69) 37 (54) 33 (49) 39 (57) 34 (50) 39 (89) 21 (48) 15 (34) 24 (55) 12 (27) 0.017 0.489 0.132 0.770 0.017
P value 0.217 0.636 0.505 0.779 0.203 0.460 0.183 0.030 0.116 0.059      
Reported Antimalarial use
Yes 12 (67) 7 (39) 11 (52) 7 (39) 8 (44) 3 (100) 2 (67) 1 (33) 2 (67) 1 (33) 0.342 0.388 0.684 0.388 0.612
No 15 (71) 15 (71) 7 (39) 15 (71) 9 (43) 38 (91) 25 (60) 21 (50) 28 (67) 19 (45) 0.059 0.355 0.859 0.702 0.858
P value 0.748 0.041 0.399 0.041 0.921 0.751 0.651 0.517 0.746 0.585      
Level of parasitaemia (parasites/μl)
< 10, 000 25 (78) 22 (69) 11 (34) 20 (63) 14 (44) 43 (92) 27 (57) 20 (43) 30 (64) 18 (38) 0.089 0.310 0.465 0.904 0.628
≥ 10, 000 33 (67) 23 (47) 27 (55) 27 (55) 24 (49) 12 (86) 5 (36) 6 (43) 7 (50) 3 (21) 0.157 0.456 0.418 0.736 0.066
P value 0.293 0.053 0.068 0.510 0.645 0.420 0.153 0.610 0.352 0.201      
  1. Boldface values indicate significant p values
  2. aTransition from rainy to dry season