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Table 2 Hepatitis B virus sero-reactivities, infection stages and genotypes in the study participants

From: Hepatitis B virus sero-profiles and genotypes in HIV-1 infected and uninfected injection and Non-injection drug users from coastal Kenya

 

Non-drug users

Non-injection drug users

Injection drug users

 
 

HIV-1(−), n = 194

HIV-1(−), n = 48

HIV-1(+), n = 139

HIV-1(−), n = 214

HIV-1(+), n = 157

P

Sero-marker

      

HBsAg

5 (2.6)

0 (0.0)

5 (3.6)

5 (2.3)

15 (9.6)

0.002

HBsAb

16 (8.2)

7 (14.6)

12 (8.6)

36 (16.8)

13 (8.3)

0.023

HBeAg

0 (0.0)

0 (0.0)

1 (0.7)

0 (0.0)

0 (0.0)

-

HBeAb

13 (6.7)

3 (6.3)

13 (9.4)

26 (12.1)

21 (13.4)

0.186

HBcAb-IgM

9 (4.6)

1 (2.1)

9 (6.5)

7 (3.3)

16 (10.2)

0.038

Infection stage

      

1

3 (1.5)

0 (0.0)

0 (0.0)

3 (1.4)

9 (5.7)

-

2

3 (1.5)

0 (0.0)

5 (3.6)

2 (0.9)

8 (5.1)

-

3

11 (5.7)

5 (10.4)

9 (6.5)

33 (15.4)

10 (6.4)

0.003

4

13 (6.7)

3 (6.3)

10 (7.2)

24 (11.2)

13 (8.3)

0.479

5

164 (84.5)

40 (83.3)

115 (82.7)

152 (71.0)

117 (74.5)

0.005

HBV genotypes

      

A1

6 (3.1)

0 (0.0)

3 (2.2)

4 (1.9)

10 (6.4)

-

  1. Data shown are number (n) and proportions (%) of subjects. HIV-1(+), human immunodeficiency virus-1 infected, HIV-1(−) uninfected. HBsAg, hepatitis B surface antigen; HBsAb, hepatitis B surface antibody; HBeAg, hepatitis B e-antigen; HBeAb, hepatitis B e-antibody; HBcAb-IgM, hepatitis B core antibody Immunoglobulin M. Statistical comparison was performed using Pearson’s Chi-square test where appropriate. Hepatitis B sero-marker test results were used to categorize hepatitis B virus infection status in to five (1–5) infection stages based on previous classifications [4, 5, 42, 43] as follows: 1 = Acute (HBsAg+, HBsAb-, HBeAg+/−, HBeAb-, HBcAb-IgM+/−); 2 = Chronic (HBsAg+, HBsAb+/−, HBeAg+/−, HBeAb+, HBcAb-IgM+/−); 3 = Vaccine type response (HBsAg-, HBsAb+, HBeAg-, HBeAb-, HBcAb-IgM-); 4 = Past, resolved or occult infection (HBsAg-, HBsAb+/−, HBeAg-, HBeAb+/−, HBcAb-IgM+/−); 5 = Uninfected (HBsAg-, HBsAb-, HBeAg-, HBeAb-, HBcAb-IgM-)