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Table 1 Patient characteristics, inflammatory response, type of surgery and outcomes

From: Surgical site infection in critically ill patients with secondary and tertiary peritonitis: epidemiology, microbiology and influence in outcomes

 

All patients (n = 305)

Non-SSI subgroup (n = 143; 46.9 %)

SSI subgroup (n = 162; 53.1 %)

P

Age (years)

64.4 ± 14.3

63.5 ± 14.4

65.3 ± 13.8

0.27

Sex (male/ female)

200 (65.6 %)/105 (34.4 %)

86 (60.1 %)/57 (39.9 %)

114 (70.4 %)/48 (29.6 %)

0.07

APACHE II

19.7 ± 7.8

20.5 ± 8.7

18.95 ± 6.6

0.07

SAPS II

36.5 ± 17.1

37.9 ± 19.3

35.1 ± 13.9

0.13

Immunosuppression

36 (11.8 %)

18 (12.6 %)

18 (11.1 %)

0.72

Neutropenia on admission

14 (4.6 %)

7 (4.9 %)

7 (4.3 %)

1.00

HIV

37 (12.1 %)

19 (13.3 %)

18 (11.1 %)

0.60

Type of infection

Secondary peritonitis

140 (45.9 %)

71 (49.6 %)

69 (42.6 %)

0.09

Tertiary peritonitis

165 (54.1 %)

72 (50.4 %)

93 (57.4 %)

0.023

Inflammatory response on admission

Sepsis

27 (8.8 %)

11 (7.7 %)

16 (9.8 %)

0.85

Severe sepsis

32 (10.5 %)

15 (10.5 %)

17 (10.5 %)

1.00

Septic shock

204 (67 %)

89 (62.2 %)

115 (71.1 %)

0.006

Multi-organ failure

42 (13.7 %)

28 (19.5 %)

14 (8.6 %)

0.003

Surgery data

Urgent surgery

276 (90.5 %)

125 (87.4 %)

151 (93.2 %)

0.11

Percutaneous surgery

41 (13.5 %)

17 (11.8 %)

24 (14.8 %)

0.10

Laparoscopic surgery

10 (3.3 %)

4 (2.8 %)

6 (3.7 %)

0.28

Laparotomy surgery

231 (75.7 %)

112 (78.5 %)

119 (73.5 %)

0.12

Combined surgery

23 (7.5 %)

10 (6.9 %)

13 (8 %)

0.14

Number of drainages on ICU admission

2 ± 1.7

1.2 ± 1.7

2.3 ± 1.8

0.01

Outcomes

ARDS

121 (39.6 %)

55 (38.4 %)

66 (40.7 %)

0.85

On mechanical ventilation

279 (91.5 %)

130 (90.9 %)

149 (92 %)

0.83

Arterial lactate on admission (mmol · dL−1)

4.3 ± 3.3

4.1 ± 3.9

5.3 ± 2.5

0.57

RRT

77 (25.2 %)

40 (28 %)

37 (22.8 %)

0.35

Total parenteral Nutrition needs (any time)

251 (82.3 %)

113 (79 %)

138 (85.2 %)

0.17

ICU stay (days)

19.8 ± 24.8

12.9 ± 14.2

22.3 ± 32.9

0.002

Hospital stay (days)

21.7 ± 30

17.6 ± 35.3

25.4 ± 26.5

0.031

In-hospital mortality

115 (38 %)

64 (45.1 %)

110 (31.7 %)

0.018

  1. Data are mean ± standard deviation or percentage
  2. SAPS simplified acute physiology score, APACHE acute physiology and chronic health evaluation, HIV human immunodeficiency virus, ARDS acute respiratory distress syndrome, RRT renal replacement therapy, ICU intensive care unit