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Table 4 Univariate and multivariate Cox analysis of risk factors for the development of herpes zoster in kidney transplant patients, (n = 450)

From: Incidence and risk factors of herpes zoster among adult renal transplant recipients receiving universal antiviral prophylaxis

Risk Factors Hazard ratio 95 % Confidence Interval p-value
Univariate analysis
Age, (years)    
 < 60 1.00 (referent)   
 ≥ 60 2.598 1.180 - 5.721 0.018
Gender    
 Female 1.00 (referent) - -
 Male 0.671 0.323-1.396 0.286
Pre-transplant VZV disease    
 No/Unknown 1.00 (referent) - -
 Yes 10.777 3.262-35.612 0.0001
Induction agent    
 None 1.00 (referent) - -
 Anti-thymocyte globulin (ATG) 0 0- n.ea 0.977
 Basiliximab 0.36 0.81-1.612 0.182
 Daclizumab 0.39 0.89-1.709 0.211
Rejection treatment    
 No 1.00 (referent) - -
 Yes 2.08 0.624-6.930 0.233
 Multivariate analysis
Age, (years)    
 < 60 1.00 (referent)   
 ≥ 60 3.995 1.790-8.915 0.001
Pre-transplant VZV disease    
 No/Unknown 1.00 (referent) - -
 Yes 16.022 4.624-55.522 0.008
Rejection treatment    
 No 1.00 (referent) - -
 Yes 5.566 1.562-19.835 0.0001
  1. an.e.: not estimated