Fig. 1From: Increasing trend of fluconazole-non-susceptible Cryptococcus neoformans in patients with invasive cryptococcosis: a 12-year longitudinal studyThe annual rate (black line) of fluconazole non-susceptible (MICs ≥16 μg/ml) Cryptococcus neoformans from 2001 to 2012 significantly increased over time (p < 0.001). There was also an increasing trend of geometric mean fluconazole MIC during the study period (p < 0.01)Back to article page