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Table 4 Influence of vitamin D status on time to sputum smear conversion by genetic sub–groups

From: Genotype-independent association between profound vitamin D deficiency and delayed sputum smear conversion in pulmonary tuberculosis

SNP, Gene

Genotype

N

Adjusted HR for 25(OH)D <25 vs. ≥25 nmol/L (95 % CI)a

P

HR, interaction term (95 % CI)

Pinteractionb

rs731236, VDR

AA

84

5.87 (3.20–10.76)

<0.001

0.84 (0.56–1.24)

0.37

 

AG

117

4.27 (2.65–6.86)

<0.001

 

GG

29

5.53 (1.92–15.94)

<0.001

rs1544410,VDR

CC

53

5.97 (2.73–13.04)

<0.001

0.79 (0.53–1.17)

0.24

 

CT

128

4.45 (2.81–7.05)

<0.001

 

TT

54

4.61 (2.25–9.43)

<0.001

rs2228570,VDR

GG

138

6.53 (3.99–10.66)

<0.001

0.61 (0.38–0.96)

0.03

 

GA

83

3.02 (1.82–5.01)

<0.001

 

AA

15

4.58 (0.56–37.25)

0.16

rs7041,DBP

AA

55

4.81 (2.49–9.32)

<0.001

1.0 (0.69–1.45)

0.98

 

AC

106

6.39 (3.61–11.30)

<0.001

 

CC

71

3.29 (1.86–5.83)

<0.001

rs4588,DBP

GG

122

3.65 (2.32–5.75)

<0.001

1.09 (0.70–1.68)

0.69

 

GT

91

6.46 (3.60–11.59)

<0.001

 

TT

21

3.92 (3.60–5.78)

<0.001

rs10500804,CYP2R1

GG

59

4.46 (2.28–8.71)

<0.001

1.06 (0.71–1.58)

0.76

 

GT

120

4.69 (2.89–7.61)

<0.001

 

TT

52

5.38 (2.35–12.31)

<0.001

rs2060793,CYP2R1

AA

10

4.47 (0.81–24.47)

0.084

0.86 (0.54–1.36)

0.53

 

AG

106

6.79 (3.86–11.94)

<0.001

 

GG

112

4.10 (2.52–6.68)

<0.001

rs10766197,CYP2R1

AA

52

4.15 (2.08–8.29)

<0.001

1.03 (0.68–1.54)

0.88

 

AG

124

5.12 (3.15–8.32)

<0.001

 

GG

56

4.82 (2.25–10.30)

<0.001

  1. SNP single nucleotide polymorphism, HR hazard ratio, 25(OH)D 25–hydroxyvitamin D, CI confidence interval, VDR vitamin D receptor, CYP2R1 vitamin D 25–hydroxylase, DBP vitamin D binding protein
  2. aadjusted for drug sensitivity profile; bnone of these were significant using a Benjamini and Hochberg procedure controlling the false discovery rate at 20 %