SNP, Gene | Genotype | N | Adjusted HR for 25(OH)D <25 vs. ≥25 nmol/L (95 % CI)a | P | HR, interaction term (95 % CI) | Pinteractionb |
---|---|---|---|---|---|---|
rs731236, VDR | AA | 84 | 5.87 (3.20–10.76) | <0.001 | 0.84 (0.56–1.24) | 0.37 |
 | AG | 117 | 4.27 (2.65–6.86) | <0.001 | ||
 | GG | 29 | 5.53 (1.92–15.94) | <0.001 | ||
rs1544410,VDR | CC | 53 | 5.97 (2.73–13.04) | <0.001 | 0.79 (0.53–1.17) | 0.24 |
 | CT | 128 | 4.45 (2.81–7.05) | <0.001 | ||
 | TT | 54 | 4.61 (2.25–9.43) | <0.001 | ||
rs2228570,VDR | GG | 138 | 6.53 (3.99–10.66) | <0.001 | 0.61 (0.38–0.96) | 0.03 |
 | GA | 83 | 3.02 (1.82–5.01) | <0.001 | ||
 | AA | 15 | 4.58 (0.56–37.25) | 0.16 | ||
rs7041,DBP | AA | 55 | 4.81 (2.49–9.32) | <0.001 | 1.0 (0.69–1.45) | 0.98 |
 | AC | 106 | 6.39 (3.61–11.30) | <0.001 | ||
 | CC | 71 | 3.29 (1.86–5.83) | <0.001 | ||
rs4588,DBP | GG | 122 | 3.65 (2.32–5.75) | <0.001 | 1.09 (0.70–1.68) | 0.69 |
 | GT | 91 | 6.46 (3.60–11.59) | <0.001 | ||
 | TT | 21 | 3.92 (3.60–5.78) | <0.001 | ||
rs10500804,CYP2R1 | GG | 59 | 4.46 (2.28–8.71) | <0.001 | 1.06 (0.71–1.58) | 0.76 |
 | GT | 120 | 4.69 (2.89–7.61) | <0.001 | ||
 | TT | 52 | 5.38 (2.35–12.31) | <0.001 | ||
rs2060793,CYP2R1 | AA | 10 | 4.47 (0.81–24.47) | 0.084 | 0.86 (0.54–1.36) | 0.53 |
 | AG | 106 | 6.79 (3.86–11.94) | <0.001 | ||
 | GG | 112 | 4.10 (2.52–6.68) | <0.001 | ||
rs10766197,CYP2R1 | AA | 52 | 4.15 (2.08–8.29) | <0.001 | 1.03 (0.68–1.54) | 0.88 |
 | AG | 124 | 5.12 (3.15–8.32) | <0.001 | ||
 | GG | 56 | 4.82 (2.25–10.30) | <0.001 |