Table 3 Determinants of time to sputum smear conversion (n = 260)

Phenotypic characteristics

Sex

Male

120

7.5 (7.5–22.5)

1.47 (1.11–1.80)

0.01

1.16 (0.91–1.51)

0.26

Female

140

22.5 (7.5–35)

Ref

-

Ref

-

Socioeconomic status^b

Lower

177

21 (7.5–30)

0.96 (0.73–1.23)

0.68

-

-

Higher

83

21 (7.5–22.5)

Ref

-

-

-

Extent of disease

Unilateral

144

7.5 (7.5–22.5)

1.38 (1.07–1.78)

0.01

1.21(0.85–1.55)

0.23

Bilateral

116

22.5 (7.5–36.5)

Ref

-

Ref

-

Sputum smear

1–99 AFB per 100 HPF

106

7.5 (7.5–22.5)

0.80 (0.6–1.01)

0.60

-

-

≥100 AFB per 100 HPF

154

22.5 (7.5–23)

Ref

-

-

-

Age

<30 years

124

21 (7.5–22.5)

1.14 (0.91–1.50)

0.33

-

-

≥30 years

136

22 (7.5–37.5)

Ref

-

-

-

25(OH)D

<25 nmol/l

140

22.5 (22.5–37.5)

4.93 (3.55–6.86)

<0.001

4.36(3.25–6.65)

<0.001

≥25 nmol/l

120

7.5 (7.5–7.5)

Ref

-

Ref

-

Drug sensitivity

Fully–sensitive / unknown

244

15 (7.5–22.5)

Ref

-

Ref

-

Multidrug–resistant

16

52.5 (Undefined–35)

3.92 (2.12–7.24)

<0.001

3.35 (1.71–6.54)

<0.001

Genotypic characteristics

rs731236, VDR

AA

84

7.5 (7.5–22.5)

0.87 (0.71–1.06)

0.16

-

-

AG

117

21 (7.5–30)

GG

29

22.5 (7.5–37.5)

rs1544410,VDR

CC

53

7.5 (7.5–22.5)

0.89 (0.73–1.08)

0.26

-

-

CT

128

21 (7.5–35)

TT

54

21.5 (7.5–23)

rs2228570,VDR

GG

138

15 (7.5–23)

1.04 (0.84–1.28)

0.70

-

-

GA

83

22.5 (7.5–22.5)

AA

15

7.5 (7.5–22.5)

rs2060793,CYP2R1

AA

10

21 (7.5–22.5)

0.88 (0.69–1.11)

0.28

-

-

AG

106

21 (7.5–23)

GG

112

21 (7.5–23)

rs10500804,CYP2R1

GG

59

15 (7.5–22.5)

1.12(0.92–1.38)

0.24

-

-

GT

120

22.5 (7.5–35)

TT

52

7.5 (7.5–22.5)

rs10766197,CYP2R1

AA

52

15 (7.5–22.5)

1.13 (0.92–1.38)

0.24

-

-

AG

124

22.5 (7.5–35)

GG

56

15 (7.5–22.5)

rs7041,DBP

AA

55

22.5 (7.5–22.5)

1.0 (0.83–1.21)

0.94

-

-

AC

106

15 (7.5–22.5)

CC

71

7.5 (7.5–23)

rs4588,DBP

GG

122

21 (7.5–23)

1.01 (0.82–1.23)

0.90

-

-

GT

91

15 (7.5–22.5)

TT

21

22.5 (15–22.5)