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Table 2 Association between virulence genes, serogroups, HUS, and hospitalization among 333 cases of STEC infection, Norway 1992–2012

From: Shiga toxin-producing escherichia coli infections in Norway, 1992–2012: characterization of isolates and identification of risk factors for haemolytic uremic syndrome

Virulence genes No. (%) of patients
   All (333) O157 (112, 33.6 %) Non-O157 (221, 66.4 %) p-valuea HUS (25, 7.5 %) Non-HUS (308, 92.5 %) p-value Hospitalizedb(141, 42.3 %) p-value
stx1   215 (64.7 %) 66 150   1c 214 <0.005 83 0.01
  stx1a 189 66 123   1 188 <0.005 75  
  stx1c 23 0 23 <0.005 0 23   7  
  stx1d 3 0 3   0 3   1  
stx2   207d (62.2 %) 109 98 <0.005 25e 182 <0.005 106 <0.005
  stx2a 85 32 53   24 61 <0.005 51 <0.005
  stx2b 32 0 32 <0.005 0 32   6 0.05
  stx2c 100 92 8 <0.005 2 98 0.01 57 <0.005
  stx2d 9 1 8   0 9   4  
  stx2g 2 0 2   0 2   NDf  
eae   246 (73.9 %) 112 134 <0.005 25 220 <0.005 117 0.02
ehxA   283 (85.0 %) 109 174 <0.005 25 258   131 <0.005
  1. aOnly p-values ≤ 0.05 were shown
  2. bNo information on hospitalization was available for 37 patients. These patients carried STEC with the following stx genes; stx1a (n = 17), stx1c (n = 1), stx1d (n = 2), stx2a (n = 6), stx2b (n = 9), stx2c (n = 10), and stx2g (n = 2) (n = number of patients) (some patients carried STEC with more than one stx subtype)
  3. cFrom one HUS patient two different non-O157 STEC isolates were included. One with stx1a and another with stx1a + stx2a and this patient was included both in the stx1 and stx1a groups as well as in the stx2 and stx2a groups
  4. dIncluding 21 patients with STEC harbouring more than one stx2 subtype; stx2a + stx2c (n = 19), stx2a + stx2d (n = 1), and stx2c + stx2d (n = 1)
  5. eOne HUS patient carried a STEC with both stx2a + stx2c and this patient was included within the stx2a group as well as in the stx2c group
  6. fND: not determined