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Table 1 Comparison of characteristics between the survival and fatality groups

From: Serum galactomannan index for early prediction of mortality in immunocompromised children with invasive pulmonary aspergillosis

Factor

Survival group (n = 30)

Fatality group (n = 15)

p-value (univariate)

p-value (multivariate)

Gender

  

0.044

 

 Male

17 (56.7)

13 (86.7)

  

 Female

13 (43.3)

2 (13.3)

 

0.104

Age (years)

13 (4-19)

11 (1-19)

0.111

 

Underlying disease

  

0.296

 

 Acute myeloid leukemia

12 (40.0)

7 (46.7)

  

 Acute lymphoblastic leukemia

13 (43.3)

4 (26.7)

  

 Severe aplastic anemia

5 (16.7)

2 (13.3)

  

 Undifferentiated acute leukemia

0 (0.0)

1 (6.7)

  

 Non-Hodgkin lymphoma

0 (0.0)

1 (6.7)

  

Remission status of the underlying diseasea

  

0.016

 

 Complete remission status

9 (36.0)

0 (0.0)

  

 Not complete remission status

16 (64.0)

13 (100.0)

 

1.000

Type of preceding chemotherapy

  

0.035

 

 No chemotherapy

6 (20.0)

1 (6.7)

  

 Induction

4 (13.3)

0 (0.0)

 

1.000

 Re-induction or salvage

9 (30.0)

9 (60.0)

 

0.999

 Consolidation

4 (13.3)

0 (0.0)

 

1.000

 Maintenance

1 (3.3)

0 (0.0)

 

1.000

 Palliative

1 (3.3)

4 (26.7)

 

0.999

 Allogeneic hematopoietic cell transplantation

5 (16.7)

1 (6.7)

 

1.000

Previous history of hematopoietic cell transplantation

14 (46.7)

8 (53.3)

0.673

 

Previous history of invasive aspergillosis

4 (13.3)

1 (6.7)

0.651

 

Duration of fever (days)

2 (0–10)

3 (0–17)

0.419

 

Duration of neutropenia at the beginning of antifungal therapy

  

1.000

 

 ≤2 weeks

14 (46.7)

7 (46.7)

  

 >2 weeks

16 (53.3)

8 (53.3)

  

Presence of other accompanying infections

11 (36.7)

4 (26.7)

0.502

 

Chest computed tomography findings

    

 Consolidations with a halo sign

21 (70.0)

14 (93.3)

0.129

 

 Consolidations without a halo sign

9 (30.0)

1 (6.7)

0.129

 

 Air-crescent sign

0 (0.0)

0 (0.0)

NA

 

 Cavity

1 (3.3)

1 (6.7)

1.000

 

Positive serum galactomannan results

23 (76.7)

14 (93.3)

0.234

 
  1. Data are median (range) or No. (%) of cases
  2. NA not available
  3. aThe remission status was determined in 38 children (25 in the survival group and 13 in the fatality group), except for children with severe aplastic anemia