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Table 4 Factors associated with the incidence of the first confirmed malaria event (n = 25) in the 1117 HIV-infected children included in the pWADA cohort. Abidjan May-August 2012

From: Effect of cotrimoxazole prophylaxis on the incidence of malaria in HIV-infected children in 2012, in Abidjan, Côte d’Ivoire: a prospective cohort study

 

N

n

Univariate analysis

Adjusted analysis

IRR

(95 % IC)

p-value

aIRR

(95 % CI)

p-value

Antiretroviral therapy (ART) and cotrimoxazole exposure

    

<0.01

  

<0.01

On ART - On cotrimoxazole

667

4

0.06

(0.01-0.28)

<0.01

0.05

(0.01-0.24)

<0.01

Off ART - On cotrimoxazole

83

1

0.13

(0.01-1.25)

0.08

0.11

(0.01-1.08)

0.06

On ART - Off cotrimoxazole

332

17

0.58

(0.17-1.99)

0.38

0.58

(0.17-1.99)

0.39

Off ART - Off cotrimoxazole

35

3

1

-

-

1

-

-

Immunodeficiency for Age a

    

0.48

  

0.09

Severe

69

3

2.19

(0.65-7.39)

0.21

4.59

(1.32-15.98)

0.02

Moderate

106

3

1.40

(0.41-4.73)

0.59

2.09

(0.61-7.19)

0.24

No/Missing

942

19

1

-

-

1

-

-

Age

    

0.17

   

<5 years

144

6

2.82

(0.98-8.13)

0.05

 

Not included

 

[5-10[years

443

11

1.64

(0.66-4.09)

0.28

   

≥10 years

530

8

1

-

-

   

Centres

    

<0.01

   

CHU de Cocody

182

1

1

-

-

   

CHU de Yopougon

344

4

2.13

(0.24-19.08)

0.50

 

Not included

 

CePReF

322

8

4.66

(0.58-37.30)

0.15

   

CIRBA

212

2

1.74

(1.56-19.25)

0.65

   

MTCT-Plus

57

10

35.20

(4.51-275.03)

<0.01

   
  1. N: number of children; n: number of malaria incident cases (only confirmed); IRR: incidence rate ratio; aIRR, adjusted incidence rate ratio; 95 % CI:95 % Confidence Interval. aUsing the 2010 WHO definition