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Table 3 Factors associated with the incidence of the first malaria event (n = 48) in the 1117 HIV-infected children included in the pWADA cohort. Abidjan May-August 2012

From: Effect of cotrimoxazole prophylaxis on the incidence of malaria in HIV-infected children in 2012, in Abidjan, Côte d’Ivoire: a prospective cohort study

  N n Univariate analysis Adjusted analysis
IRR (95 % IC) p-value aIRR (95 % CI) p-value
Antiretroviral therapy (ART) and cotrimoxazole exposure      <0.01    <0.01
On ART - On cotrimoxazole 667 7 0.07 (0.02-0.21) <0.01 0.05 (0.02-0.18) <0.01
Off ART - On cotrimoxazole 83 2 0.16 (0.03-0.80) 0.03 0.13 (0.02-0.69) 0.02
On ART - Off cotrimoxazole 332 34 0.69 (0.27-1.77) 0.44 0.69 (0.27-1.77) 0.44
Off ART - Off cotrimoxazole 35 5 1 - - 1 - -
Immunodeficiency for Age a      0.38    0.02
Severe 69 5 1.87 (0.73-4.76) 0.19 4.03 (1.55-10.47) <0.01
Moderate 106 6 1.44 (0.61-3.40) 0.41 2.14 (0.89-5.14) 0.09
No/Missing 942 40 1 - - 1 - -
Age      0.14    
<5 years 144 11 2.18 (1.04-4.58) 0.04   Not included  
[5-10[years 443 18 1.13 (0.59-2.16) 0.70    
≥10 years 530 19 1 - -    
Centres      <0.01    
CHU de Cocody 182 1 1 - -    
CHU de Yopougon 344 9 4.80 (0.61-37.87) 0.14   Not included  
CePReF 322 20 11.66 (1.56-86.91) 0.02    
CIRBA 212 7 6.11 (0.75-49.65) 0.09    
MTCT-Plus 57 11 38.72 (5.00-299.97) <0.01    
  1. N: number of children; n: number of malaria incident cases (confirmed and probable); IRR: incidence rate ratio; aIRR, adjusted incidence rate ratio; 95 % CI:95 % Confidence Interval. aUsing the 2010 WHO definition