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Table 2 Susceptibility of the 144 serotype 14 isolates to eight antimicrobials throughout the study period

From: Dynamics of serotype 14 Streptococcus pneumoniae population causing acute respiratory infections among children in China (1997–2012)

Antibiotics

Susceptibility and MIC

1997–2000 (n = 19)

2001–2003 (n = 38)

2004–2006 (n = 24)

2007–2009 (n = 35)

2010–2012 (n = 28)

Total (n = 144)

PEN

I%

0

0

0

2.9

0

0.7

 

MIC50(μg/ml)

0.016

0.032

0.5

0.75

0.5

0.5

 

MIC90(μg/ml)

0.75

0.5

1

1.5

1

1

 

MIC Range(μg/ml)

0.004–1.5

0.008–0.75

0.012–1.5

0.008–3

0.25–1.5

0.004–3

AMC

MIC50(μg/ml)

0.016

0.023

0.5

0.5

0.5

0.38

MIC90(μg/ml)

0.75

0.5

1

1

0.75

1

 

MIC Range(μg/ml)

0.008–1

0.008–1

0.016–2

0.008–1

0.25–1.5

0.008–2

CXM

I%

10.5

13.2

50.0

65.7

75.0

43.8

 

R%

0

0

4.2

20.0

10.7

7.6

 

MIC50(μg/ml)

0.023

0.032

1.5

2

2

1.5

 

MIC90(μg/ml)

2

1.5

3

4

4

3

 

MIC Range(μg/ml)

0.016–2

0.008–2

0.016–4

0.032–4

0.25–6

0.008–6

CRO

I%

0

0

4.2

17.1

10.7

6.9

 

R%

0

0

0

0

7.1

1.4

 

MIC50(μg/ml)

0.016

0.032

0.5

0.75

0.5

0.38

 

MIC90(μg/ml)

0.38

0.38

1

1.5

2

1

 

MIC Range(μg/ml)

0.004–0.5

0.008–0.75

0.016–1.5

0.008–2

0.25–8

0.004–8

IPM

I%

10.5

18.4

50.0

62.9

100

49.3

 

MIC50(μg/ml)

0.012

0.032

0.094

0.125

0.19

0.094

 

MIC90(μg/ml)

0.125

0.125

0.19

0.19

0.25

0.19

 

MIC Range(μg/ml)

0.004–0.125

0.004–0.19

0.012–0.19

0.012–0.19

0.125–0.38

0.004–0.38

TCY

I%

0

5.3

8.3

40.0

82.1

28.5

 

R%

94.7

86.8

75.0

28.6

10.7

56.9

SXT

I%

0

0

0

0

0

0

 

R%

84.2

86.8

45.8

20.0

3.6

47.2

CHL

R%

52.6

18.4

20.8

0

0

15.3

  1. PEN penicillin, AMC amoxicillin–clavulanic acid, CXM cefuroxime, CRO ceftriaxone, IPM imipenem, TCY tetracycline, CHL chloramphenicol, SXT trimethoprim–sulfamethoxazole, - no data for disk diffusion test, I intermediate, R resistant, MIC50 minimum inhibitory concentration at which 50 % of the strains were inhibited, MIC90 minimum inhibitory concentration at which 90 % of the strains were inhibited, MIC range range of minimum inhibitory concentration