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Table 5 MLST analysis on pairs of CoS and CoR strains obtained from the same patient. Time to switch is intended as the time-interval between the first CoS strain isolated from a clinical sample and the first CoR strain isolated from the same patient

From: Prevalence of Klebsiella pneumoniae strains producing carbapenemases and increase of resistance to colistin in an Italian teaching hospital from January 2012 To December 2014

  Strains with Stable ST
Patient ST of the first CoS strain isolated Sample type Sample type of first clinical CoS ST of CoR strain isolated Sample type Time to switch from CoR to CoS (days)
1 554 SRS Arterial catheter - bronchial aspirate 36
2 512 SRS skin swab - urine 26
3 307 SRS skin swab - skin swab 42
4 512 SRS skin swab - SRS 123
5 512 SRS drainage fluid - drainage fluid 28
6 512 urine urine - urine 17
7 512 SRS bronchial aspirate - SRS 74
8 1543 SRS - - SRS 50
9 512 SRS bronchial aspirate - bronchial aspirate 31
10 512 SRS bronchial aspirate - bronchial aspirate 6
11 554 SRS - - bronchial aspirate na
12 512 SRS bronchial aspirate - blood 24
13 258 SRS urine - urine 8
       Median
29.5 days
  Switched ST
Patient ST of the first CoS strain isolated Sample type Sample type of first clinical CoS ST of CoR strain isolated Sample type Time to switch from CoR to CoS (days)
14 15 SRS urine 512 SRS 167
15 554 urine urine 512 SRS 67
16 2581 SRS skin swab 512 SRS 34
17 554 SRS arterial catheter 1733 (554 SLV) drainage fluid 54
       Median:
60.5 days
  1. 1 simultaneous isolation of a ST258 CoS strains and a ST512 CoR strain from the same sample at the first detection”
  2. CoR colistin resistant, CoS colistin susceptible, MLST Multilocus sequence typing, na not applicable, SLV single locus variant, SRS surveillance rectal swab, ST sequence typing