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Table 2 Diagnostic performance of GM-ELISA and facC-PCR when testing serum samples

From: Combining standard clinical methods with PCR showed improved diagnosis of invasive pulmonary aspergillosis in patients with hematological malignancies and prolonged neutropenia

Parameter

Platelia Aspergillus-EIA

facC-PCR

% Se (95 % CI)

52,63 (28,90-75,51)

69,23 (48,21-85,63)

% Sp (95 % CI)

98,31 (90,88-99,72)

68,85 (55,71-80,09)

LR+

31,05

2,22

LR-

0,48

0,45

PV+ %

90,91

48,65

PV- %

86,57

84,00

DOR (95 % CI)

64,44 (7,342-565,694)

4,974 (1,81-13,434)

% Se (95 % CI)

37,5 (17,97-57,48)

84 (65,46-93,19)

% Sp (95 % CI)

96 (87,02-99,54)

83,02 (70,19-91,91)

LR+

9,5491

4,85

LR-

0,6651

0,21

PV+ %

89,4268

75,68

PV- %

62,9298

88,00

DOR (95 % CI)

15,33 (3,117-75,420)

28,667 (9,048-90,823)

P value

P < 0,0001

P < 0,0001

  1. Calculated diagnostic performance for Platelia Aspergillus GM-EIA and facC-PCR at the standard cutoff OD450/620≧0.5 for GM-EIA and by considering ≧1 positive Cq as significant/triplicate. Performance parameters calculated after stratification corrections based on autopsy data are highlighted with bold letters. Se sensitivity, Sp specificity, 95 % CI 95 % confidence interval, LR+ likelihood ratio positive, LR- likelihood ratio negative, DOR, PV+ positive predictive value, PV- negative predictive values
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BMC Infectious Diseases

ISSN: 1471-2334

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