From: Scabies: an ancient global disease with a need for new therapies
Study | Drugs | Dosage | Treatment regimen | Contraindication | Disadvantages | Comments |
---|---|---|---|---|---|---|
 | Topical | |||||
Benzyl benzoate | 25Â % solution | one or several consecutive 24-h applications | pregnant women and infants | burning or stinging, pruritus, dermatitis, convulsions (rare) | In use since 1930s; possible neurological complications with misuse; withdrawn in the European Union due to neurotoxicity concerns | |
Permethrin | 5 % cream (8–14 h) then wash off | apply overnight | infants aged <2 months | mild burning, itching stinging, pruritus, erythema, tingling, persistent excoriation, dystonia (rare), convulsions (rare) | in use since the 1980s; relatively expensive; growing resistance among scabies mites poor compliance reported in mass community intervention programs | |
Sulphur | 2–10 % precipitate in petroleum base | apply for 24 h, and then wash and reapply repeat applications for 3 days |  | noxious, malodorous messy; not given as first-line agents; multiple applications required; can cause skin irritation; | has been used for centuries; indicated in infants, pregnant and lactating women; inexpensive | |
 | Oral | |||||
Ivermectin | 200 μg/kg orally repeated after 1–2 weeks |  | children aged <5 years.; children <15 kg; pregnant or lactating women | transient side effects: gastrointestinal disorders; pustular rash, cellulitis; abdominal pain, diarrhoea, headache, vomiting, hypotension, toxic epidermal necrosis, mucosal drug eruption, fever, anorexia, lymph node swelling, eosinophilia, pain of joint and muscles, mazzotti reaction | in use since 1980’s (for the mass treatment of onchocerciasis, and filariasis); not approved for the treatment of typical scabies (except in Japan, Brazil, France); only indicated if symptoms persists 3 weeks after application of benzyl benzoate or permethrin; no ovicidal activity, thus repeat treatment is required; one report of increased deaths among elderly patients during scabies outbreak in an institutional setting (1997); there has been considerable criticism on the validity of this report, no other studies have replicated these findings |