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Table 1 Evidence of resistance to classical treatments used in scabies management

From: Scabies: an ancient global disease with a need for new therapies

Study Indicative cure rate Drugs and treatment regimen Comments
Topical
Benzyl benzoate
[45] Moberg et al., 1984 (43 %; 6/14) benzyl benzoate (22.5 %) case report
[46] Yonkosky et al., 1990 (12 %; 23/195) benzyl benzoate (50 %) case study
[47] Nnoruka et al., 2001 (48 %; 14/29) benzyl benzoate (22.5 %) clinical exploratory study
[38] Glaziou et al., 1993 (48 %; 10/21) benzyl benzoate (10 %) RCT
Permethrin
[38] Leibowitz, 1993 (0 %; 0/11) permethrin 5 % cream un-controlled case study
[40] Fraser, 1994   permethrin (in vitro study)
[48] Walton et al., 2000   " (in vitro study)
[37] Pasay et al., 2006   " (in vitro study)
[39] Pasay et al., 2008   " (in vitro study)
[33] Mounsey et al., 2008   " (in vitro study)
[34] Mounsey et al., 2009   " (in vitro study)
[49] Saqib et al., 2012    quasi clinical study, re-infestation after successful treatment (7 %; 4/60)
[50] Huffam et al., 1997 (0 %; 0/20) permethrin 5 % cream crusted scabies   
Sulphur
[51] Coskey RJ, 1979 (0 %; 0/1) sulphur 5 % in an ointment case report
Oral
Ivermectin
[52] Glaziou et al., 1993 (70 %; 16/23) single dose, 100 μg/kg RCT, poor efficacy partly attributed to the lower dose used in the study
[30] Currie et al., 1994 (0 %; 0/1) two doses, 200 μg/kg case report, crusted scabies
[33] Currie B.J 1999   five dose regimen, 200 μg/kg crusted scabies, monthly administration failed to prevent reinfestation
[36] Currie et al., 2004 (0 %; 0/2) seven doses, 270 μg/kg reinfestation following seven doses, unpublished observations
[53] Brooks, et al., 2002 (56 %; 24/43) single dose, 200 μg/kg results evaluated at 3 weeks post treatment
[33] Mounsey et al., 2008    In vitro study
[41] van den Hoek et al., 2008 (0 %; 0/7)   case report
[34] Mounsey et al., 2009    In vitro study
[42] Ly et al., 2009   (30 %;16/53) single dose, 150–200 μg/kg first RCT to report resistance of ivermectin
[43] Rizvi et al., 2011   (78 %; 38/50) single dose, 200 μg/kg quasi clinical study
[54] Fujimoto et al., 2014 (0 %; 0/1) 6000 μg/week* 3 + 12000 μg/week *3 case report
[49] Saqib et al., 2012    quasi clinical study, re-infestation after successful treatment (7 %; 4/60)
[50] Huffam et al., 1997 (60 %; 12/20) one-three doses, 200 μg/kg combined with topical scabicide and keratolytic therapy crusted scabies