Univariate analysis | Multivariate analysis | |||||
---|---|---|---|---|---|---|
OR | 95 % CI | P value | aOR | 95 % CI | P value | |
Carriage of Pnc* | ||||||
Otalgia + fever ≥38.5 °C | 1.39 | 1.26;1.53 | <10−4 | 1.29 | 1.17;1.42 | <10−4 |
Daycare centre | 1.33 | 1.21;1.46 | <10−4 | 1.61 | 1.46;1.78 | <10−4 |
Siblings | 1.32 | 1.20;1.45 | <10−4 | 1.45 | 1.31;1.60 | <10−4 |
Age <1 year | 1.03 | 0.94 ;1.14 | 0.48 | 1.04 | 0.95 ;1.15 | 0.39 |
Recent use of cephalosporin | 0.98 | 0.86;1.11 | 0.74 | |||
Bilateral AOMa | 0.94 | 0.84;1.06 | 0.33 | |||
Otitis-prone childrenb | 0.91 | 0.79;1.04 | 0.16 | |||
Periods (post-PCV13) | 0.86 | 0.78;0.94 | 0.002 | 0.84 | 0.77 ;0.93 | 0.01 |
History of AOMb | 0.86 | 0.77;0.96 | 0.005 | |||
Hi carriage | 0.79 | 0.72 ;0.86 | <10−4 | |||
Recent use of antibiotics | 0.78 | 0.71 ;0.86 | <10−4 | 0.73 | 0.66 ;0.81 | <10−4 |
Conjunctivitis | 0.47 | 0.42;0.52 | <10−4 | 0.47 | 0.42;0.52 | <10−4 |
Carriage of RSP Pnc** | ||||||
Recent use of antibiotics | 1.88 | 1.66 ;2.14 | <10−4 | 1.78 | 1.56 ;2.03 | <10−4 |
Day care centre | 1.68 | 1.48;1.91 | <10−4 | 1.55 | 1.36 ;1.77 | <10−4 |
Recent use of cephalosporin | 1.63 | 1.38;1.92 | <10−4 | |||
Otitis-prone childrenb | 1.60 | 1.33;1.93 | <10−4 | |||
History of AOMb | 1.58 | 1.36;1.83 | <10−4 | |||
Bilateral AOMa | 1.15 | 0.98;1.35 | 0.08 | |||
Age <1 year | 1.08 | 0.96 ;1.23 | 0.21 | 1.19 | 1.04 ;1.35 | 0.009 |
Conjunctivitis | 1.08 | 0.93;1.26 | 0.33 | |||
Hi carriage | 0.95 | 0.84 ;1.08 | 0.46 | |||
Otalgia + fever ≥38.5 °C | 0.93 | 0.82;1.06 | 0.27 | |||
Periods (post-PCV13) | 0.72 | 0.63 ;0.81 | <10−4 | 0.71 | 0.62 ;0.81 | <10−4 |
Siblings | 0.70 | 0.62 ;0.80 | <10−4 | 0.75 | 0.65 ;0.85 | <10−4 |
Carriage of Hi*** | ||||||
Conjunctivitis | 4.22 | 3.76 ;4.74 | <10−4 | 4.10 | 3.54 ;4.76 | <10−4 |
Daycare centre | 1.74 | 1.58 ;1.91 | <10−4 | 1.93 | 1.70;2.19 | <10−4 |
History of AOMb | 1.65 | 1.48 ;1.83 | <10−4 | |||
Otitis-prone childrenb | 1.54 | 1.34 ;1.77 | <10−4 | |||
Siblings | 1.49 | 1.36 ;1.64 | <10−4 | 1.82 | 1.60;2.07 | <10−4 |
Bilateral AOMa | 1.47 | 1.31 ;1.65 | <10−4 | 1.33 | 1.17 ;1.51 | <10−4 |
Recent use of antibiotics | 1.42 | 1.29;1.56 | <10−4 | 1.28 | 1.12;1.45 | <10−4 |
Age <1 year | 1.37 | 1.25 ;1.50 | <10−4 | 1.49 | 1.31;1.69 | <10−4 |
Recent use of cephalosporin | 1.19 | 1.05 ;1.35 | 0.005 | |||
Periods (post-PCV13) | 1.18 | 1.08;1.29 | <10−3 | 1.23 | 1.05;1.44 | 0.01 |
Otalgia + fever ≥38.5 °C | 0.84 | 0.76;0.92 | <10−3 | |||
Pnc carriage | 0.79 | 0.72 ;0.86 | <10−4 | |||
Carriage of ß-lactamase producing Hi**** | ||||||
Otitis-prone childrenb | 1.27 | 0.99 ;1.64 | 0.06 | |||
Recent use of cephalosporin | 1.21 | 0.96 ;1.53 | 0.11 | |||
History of AOMb | 1.18 | 0.94;1.48 | 0.16 | |||
Recent use of antibiotics | 1.17 | 0.97 ;1.40 | 0.11 | |||
Age <1 year | 1.16 | 0.96;1.40 | 0.12 | 0.86 | 0.72;1.04 | 0.13 |
Conjunctivitis | 1.10 | 0.91 ;1.33 | 0.32 | |||
Bilateral AOMa | 0.96 | 0.76 ;1.23 | 0.76 | |||
Otalgia + fever ≥38.5 °C | 0.94 | 0.78;1.14 | 0.52 | |||
Siblings | 0.91 | 0.75 ;1.10 | 0.33 | |||
Daycare centre | 0.90 | 0.75;1.08 | 0.27 | |||
Pnc carriage | 0.89 | 0.74 ;1.08 | 0.24 | |||
Periods (post-PCV13) | 0.65 | 0.54 ;0.78 | <10−4 | 0.65 | 0.54 ;0.79 | <10−4 |