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Table 4 Clinical and microbiological characteristics associated with patients experiencing cure, without relapse/reinfection, or chronic infectiona

From: Clinical infectious outcomes associated with biofilm-related bacterial infections: a retrospective chart review

 

Total cure, initial infection (n = 101)

Relapse/reinfection, or chronic infection (n = 30)

P-value

Multivariate P-value

Median Age, years (IQR)

28 (23, 41)

30 (22, 41)

0.44

 

Male

91 (91 %)

24 (80 %)

0.14

NS

Military Service

75 (75 %)

17 (57 %)

0.06

NS

Combat Trauma

68 (68 %)

16 (53 %)

0.16

NS

Burn

38 (38 %)

14 (47 %)

0.37

 

% TBSA burn (IQR)

53.5 % (28, 60)

77 % (59, 85)

<0.01

NS

Coronary Artery Disease

3 (3 %)

0

0.34

 

Chronic Kidney Disease

0

0

  

ESRD

0

0

  

Diabetes

6 (6 %)

5 (17 %)

0.06

NS

Median Hct on Culture Date (IQR)

24.2 (22, 30)

23.6 (22, 27)

0.53

 

Median WBC on Culture Date (IQR)

9.7 (7, 13)

7 (5, 12)

0.11

NS

Median ESR on Culture Date (IQR)

91.5 (65, 114)

106 (104, 114)

0.48

 

Median CRP on Culture Date (IQR)

18.9 (7, 21)

16.1 (9, 30)

0.14

NS

Received Appropriate Empiric Antibiotics

39 (39 %)

16 (53 %)

0.28

 

Median Prior Duration of Antibiotics, Days (IQR)

6 (2, 8)

4 (2, 9)

0.57

 

A. calcoaceticus-baumannii complex

34 (34 %)

6 (20 %)

0.41

 

E. coli

19 (19 %)

5 (17 %)

0.79

 

K. pneumoniae

25 (25 %)

7 (23 %)

0.87

 

P. aeruginosa

9 (9 %)

7 (23 %)

0.03

NS

S. aureus

14 (14 %)

6 (20 %)

0.41

 

MSSA

1 (1 %)

5 (17 %)

<0.01

NS

MRSA

12 (13 %)

1 (3 %)

0.14

NS

Polymicrobial Event

41 (41 %)

7 (23 %)

0.09

NS

Blood Culture

23 (23 %)

11 (37 %)

0.13

NS

Central Line Associated

9 (39 % n = 23)

0

0.12

NS

Respiratory Culture

4 (4 %)

4 (13 %)

0.08

NS

Urine Culture

6 (6 %)

4 (13 %)

0.24

 

Foley Catheter Associated

2

0

0.44

 

Wound Culture

68 (68 %)

11 (37 %)

<0.01

NS

Orthopedic Device Related

13 (19 %, n = 68)

5 (25 %, n = 11)

0.50

 

Median Number of Surgeries (IQR)

7 (4, 9)

3 (2, 9)

0.15

NS

  1. aPatients who died during initial infection are excluded from this analysis