Table 1 Study site and population characteristics
|  | Gugulethu TB Clinic (Cape Town, South Africa) | Kanyama TB Clinic (Lusaka, Zambia) | St. Mary’s Day Clinic (Durban, South Africa) | Ifisi Day Clinic (Mbeya, Tanzania) | Overall |
|---|---|---|---|---|---|
No. patients enrolled in parent RCT | 419 | 400 | 193 | 83 | 1095 |
HIV-infected | 133 (32) | 268 (67) | 114 (59) | 49 (59) | 564 (52) |
HIV uninfected | 278 (66) | 130 (33) | 70 (35) | 34 (41) | 512 (47) |
HIV testing refused | 8 (2) | 2 (<1) | 9 (5) | 0 (0) | 19 (1) |
Demographics of HIV-infected/testing refused patients included in primary analysis (N = 583) | |||||
|  | N = 141 | N = 270 | N = 123 | N = 49 | N = 583 |
Median age, years (range, IQR) | 35 (19-79, 30-40) | 35 (19-79, 30-40) | 36 (20-63, 29-42) | 36 (17-72, 33-48) | 36 (17-79, 30-41) |
Women (%)a | 81 (58) | 99 (37) | 65 (53) | 27 (55) | 272 (46) |
Previous TBb (%) | 69 (49) | 42 (16) | 37 (30) | 2 (4) | 150 (26) |
Median CD4 cell count, cells/ml (range, IQR)c | 261 (6-1089, 137-410) | 201 (1-1251, 104-339) | 231 (2-1157, 106-494) | 91 (1-423, 33-213) | 210 (1-1251, 103-375) |
HIV-infected on ARTd (%) | 51/133 (38) | 54/268 (20) | 28/114 (25) | 2/49 (4) | 135/564 (24) |
TB outcomes | |||||
Sputum TB culture-positive patientse (%) | 39 (28) | 100 (37) | 25 (20) | 17 (35) | 181 (31) |
Clinical TBf (%) | 17 (12) | 26 (10) | 6 (5) | 4 (8) | 53 (9) |
TB-related morbidity at baseline in culture-positive patients | |||||
Median TBscore (IQR)g | 4 (3-5) | 6 (4-7) | 5 (4-6) | 7 (5-9) | 5 (4-7) |