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Table 2 Comparison of diagnostic methods for the detection of Mtb in hospitalized versus ambulatory and in smear-positive versus smear-negative patients

From: Evaluation of Microscopic Observation Drug Susceptibility (MODS) and the string test for rapid diagnosis of pulmonary tuberculosis in HIV/AIDS patients in Bolivia

A. All patients Hospitalized patients Ambulatory patients
TB+ (n = 48) Diagnostic yield (95 % CI) TB+ (n = 35) Diagnostic yield (95 % CI) TB+ (n = 13) Diagnostic yield (95 % CI)
MODS 46 95.8 % (85.7-99.5) 34 97.1 % (85.1-99.9) 12 92.3 % (64.0-99.8)
LJ 38 79.2 % (65.0-89.5) 31 88.6 % (73.3-96.8) 7 53.8 % (25.1-80.8)
ZN 30 62.5 % (47.3-76.0) 22 62.9 % (44.9-78.5) 8 61.5 % (31.6-86.1)
B. All patients Smear-positive Smear-negative
TB+ (n = 48) Diagnostic yield (95 % CI) TB+ (n = 30) Diagnostic yield (95 % CI) TB+ (n = 18) Diagnostic yield (95 % CI)
MODS 46 95.8 % (85.7-99.5) 29 96.6 % (82.8-99.9) 17 94.4 % (72.7-99.9)
LJ 38 79.2 % (65.0-89.5) 27 90.0 % (73.4-97.9) 11 61.0 % (35.7-82.7)
  1. TB+ was defined as any patient with sputum or gastric sample that yielded a positive culture result by LJ or MODS. As the reference standard is a composite from all tests that are being evaluated, we can only comment on diagnostic yield rather than sensitivity and specificity. Panel A: Comparison of diagnostic yield of MODS versus LJ and ZN in all patients, hospitalized patients, and ambulatory patients who were TB positive. Panel B: Subgroup comparison of the diagnostic yield of MODS versus LJ in culture positive patients, sub-grouped into all patients, smear positive patients, and smear negative patients
  2. n number of patients in each group; CI confidence interval; TB + samples tested positive for Mtb by each respective method (MODS, LJ, or ZN)