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Table 3 Unadjusted and adjusted baseline associates of treatment non-adherence in patients with culture-confirmed TB

From: Psychological distress and its relationship with non-adherence to TB treatment: a multicentre study

 

Univariate analysis

Multivariate analysis

 

Crude odds ratio (95 % CI)

P-value

Adjusted odds ratio (95 % CI)

P-value

Demographic and clinical characteristics

Age

0.997 (0.970, 1.024)

0.8457

0.988 (0.947, 1.029)

0.5563

Male

0.859 (0.491, 1.517)

0.5971

0.895 (0.402, 2.246)

0.8951

Previously had TB

0.729 (0.346, 1.445)

0.3832

-

-

HIV-infected

1.227 (0.693, 2.215)

0.4889

1.358 (0.557, 3.421)

0.5054

TBscore

0.868 (0.748, 0.998)

0.0524

0.639 (0.497, 0.797)

0.0001

Allocation arm Xpert MTB/RIF

2.038 (1.161, 3.648)

0.0144

2.174 (0.985, 5.015)

0.05993

K-10 score

1.073 (1.039, 1.112)

<0.0001

1.082 (1.033, 1.137)

0.0012

Substance use

Tobacco smoker

0.651 (0.325, 1.239)

0.2055

-

-

Alcohol consumption

    

 Never

1.00 (reference)

N/A

1.00 (reference)

N/A

 Social

0.629 (0.296, 1.279)

0.2122

0.505 (0.177, 1.364)

0.1874

 Regular

0.701 (0.327, 1.435)

0.3422

0.707 (0.243, 1.986)

0.5137

 Heavy

2.371 (0.624, 9.029)

0.1933

14.83 (2.083, 122.9)

0.0090

Educational characteristics

Educational level

    

 None

0.375 (0.030, 4.299)

0.4167

-

-

 Primary school

0.500 (0.077, 4.022)

0.4668

-

-

 Middle school

0.330 (0.049, 2.727)

0.2539

-

-

 High School

0.684 (0.107, 5.428)

0.6874

-

-

 Intermediate or post-high school diploma

0.789 (0.112, 6.743)

0.81183

-

-

 Graduate or post-graduate

0.00 (reference)

N/A

-

-

TB health literacy score

0.885 (0.809, 0.967)

0.0071

0.798 (0.696, 0.907)

0.0008

Economic characteristics

Unemployed or retired

  

-

-

Personal monthly income

    

 Tier 1

*

0.9839

-

-

 Tier 2

*

0.9840

-

-

 Tier 3

*

0.9838

-

-

 Tier 4

1.00 (reference)

N/A

-

-

Household monthly income

    

 Tier 1

0.353 (0.102, 1.181)

0.089747

0.288 (0.064, 1.264)

0.0997

 Tier 2

0.275 (0.082, 0.898)

0.031567

0.350 (0.082, 1.445)

0.1462

 Tier 3

0.202 (0.039, 0.900)

0.041743

0.156 (0.024, 0.922)

0.0462

 Tier 4

1.00 (reference)

N/A

1.00 (reference)

N/A

Sites

 Cape Town

0.427 (0.121 1.593)

0.1868

-

-

 Harare

3.709 (1.308, 12.285)

0.01956

-

-

 Lusaka

1.036 (0.358, 3.461)

0.9499

-

-

 Mbeya

0.900 (0.193, 3.980)

0.8888

-

-

 Durban

1.00 (reference)

N/A

-

-

  1. Cells marked with a dash indicate variables excluded from the final multivariate model
  2. *indicates where accurate estimation of the odds ratio failed due to too few observations
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BMC Infectious Diseases

ISSN: 1471-2334

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