Risk factors for early mortality after AIDS in the cART era: A population-based cohort study in Italy

BMC Infectious Diseases

Table 3 Distribution of AIDS cases according to AIDS-defining diseases and odds ratios^a for early mortality. Italy, 1999-2009

	AIDS cases	Early mortality
	No.	No. (%)	OR (95 % CI)
AIDS-defining diseases^b
Infectious diseases
Pneumocystis carinii pneumonia	2650	393 (14.8)	1^c
Tuberculosis	1089	126 (11.6)	0.81 (0.65-1.00)
Candidiasis	2943	404 (13.7)	0.84 (0.72-0.98)
Recurrent pneumonia	466	62 (13.3)	0.91 (0.68-1.23)
Other infections	1476	266 (18.0)	1.22 (1.02-1.45)
Brain toxoplasmosis	856	175 (20.4)	1.43 (1.16-1.75)
Neoplasms
Invasive cervical cancer	104	9 (8.7)	0.59 (0.29-1.24)
Kaposi sarcoma	773	80 (10.4)	0.82 (0.63-1.07)
Immunoblastic lymphoma	707	234 (33.1)	3.18 (2.59-3.89)
Burkitt lymphoma	286	95 (33.2)	3.48 (2.62-4.62)
Primary brain lymphoma	85	54 (63.5)	11.66 (7.32-18.57)
Other conditions
HIV encephalopathy	999	231 (23.1)	1.55 (1.28-1.88)
HIV wasting syndrome	1655	436 (26.3)	1.78 (1.52-2.09)
Progressive multifocal leukoencephalopathy	463	192 (41.5)	4.21 (3.37-5.27)
No. of AIDS-defining diseases at diagnosis
1	11670	2048 (17.6)	1^c
2	2261	510 (22.6)	1.27 (1.13-1.42)
≥3	621	199 (32.1)	1.97 (1.64-2.37)

^aOdds ratios (OR) and 95 % confidence intervals (CI) estimated using multivariate logistic regression models adjusted for age, gender, area of residence, education, HIV transmission mode, year and CD4 cell count at AIDS diagnosis
^bFor patients with more than one AIDS-defining disease, only the most severe was considered
^cReference category

ISSN: 1471-2334