Table 6 Treatment regimens, outcomes, and mortality in hepatic TB case series
Lead Author (Year) | N | Treatment regimens (n) | Median duration (months) | Outcomes | Overall mortality (%) | Comments |
|---|---|---|---|---|---|---|
Alvarez (1983) [29] | 130 | H, S, E, PAS (130), biliary stenting (6) | ND | 87 improved on H, S, E, PAS; 3 decompressed with stent | 12 | Author recommends treatment for 12Â months |
Essop (1984) [18] | 96 | <2 drugs (10); >2 drugs (no R, H) (29); R, H, +others (16); no TX (37); undocumented (4) | ND | 52 improved; 40 died; 4 undocumented | 42 | No TX mortality: 95%; <2 drug mortality: 20%; R, H, +others mortality: 0% |
Kok (1999) [44] | 5 | ATT (5) | ND | 5 improved | 0 | All local hepatic TB |
Huang (2003) [49] | 5 | ATT (3), lobectomy (1), hepatectomy (2); no TX (2) | ND | 4 improved; 1 died | 20 | All local hepatic TB |
Desai (2006) [14] | 7 | R, H, Z, E for 2Â months, then R, H for 4Â months (7) | 6 | 6 improved; 1 died | 14 | All local hepatic TB |
Amarapurkar (2008) [76] | 38 | R, H, Z, E for 2Â months, then R, H for 10Â months (38) | 12 | 38 improved | 0 | None |
Tai (2008) [19] | 10 | ATT (10), left hepatic resection (3) | ≥6 | 9 improved; 1 LTFU | 0 | None |
Hwang (2009) [50] | 12 | ATT (12) | 12 | 10 improved; 2 had persistent disease | 0 | Disease persisted in patients w/ liver abscesses |
Gounder (2012) [30] | 20 | R, H, Z, E (20) | 9 | 12 improved; 8 died | 40 | 2 patients died from MDR/XDR-TB |