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Table 2 Modeled CD4 gains after cART initiation for participants vaccinated before or after HIV diagnosis

From: Association between hepatitis B vaccine antibody response and CD4 reconstitution after initiation of combination antiretroviral therapy in HIV-infected persons

 

Median [IQR] Change in CD4 Cell Count (cells/mm3) 1 Year After cART Initiation*

Characteristic

Vaccinated before HIV diagnosis

P value

Vaccinated between HIV diagnosis and cART Initiation

P value

CD4 <200 cells/mm3at cART initiation

−208 [−283, −134]

<0.001

−188 [−295, −81]

<0.001

CD4 200–350 cells/mm3 at cART initiation

−141 [−189, −94]

<0.001

−81 [−167, 5]

0.067

HBV vaccine responder at cART initiation

−18 [−79, 42]

0.551

26 [−55, 108]

0.528

  1. cART, combination antiretroviral therapy; IQR, interquartile range; HBV, hepatitis B virus; responder, antibody to HBV surface antigen ≥10 IU/L.
  2. *Model adjusted for HBV vaccine response status, race, gender, age at cART initiation, and AIDS before cART at baseline.