How to treat fungal infections in ICU patients

BMC Infectious Diseases

Table 2 Treatment of documented invasive candidiasis

	First line	Alternatives
ESCMID (2012)	- Anidulafungin 200 mg loading dose, then 100 mg/day	- Liposomal amphotericin B 3 mg/kg
	- Caspofungin 70 mg loading dose, then 50 mg/day	- Voriconazole 3–6 mg/kg/day
	- Micafungin 100 mg	- Fluconazole 400–800 mg
	- Micafungin 100 mg	- Amphotericin B lipid complex 5 mg/kg
IDSA (2009)	Stable patients	- Lipid formulations of amphotericin B 3–5 mg/kg daily - Amphotericin B deoxycholate 0.5-1 mg/kg daily
	- Fluconazole 800 mg loading dose, then 400 mg
	Unstable patients or recent use of fluconazole
	- Anidulafungin 200 mg loading dose, then 100 mg/day	- Voriconazole 400 mg twice daily for 2 doses, then 200 mg twice daily
	- Caspofungin 70 mg loading dose, then 50 mg/day
	- Micafungin 100 mg/day

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