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Table 4 Regression analysis for the risk of death in vertically HIV-infected children and adolescents

From: Mortality in children and adolescents vertically infected by HIV receiving care at a referral hospital in Vitoria, Brazil

Variable Crude OR Adjusted OR*
p-value OR 95% CI p-value OR 95% CI
Age-group at admission to service
< 1 year 0.001 4.74 1.96 11.46 0.005 10.20 1.99 52.21
≥ 1 year   1.00     1.00   
ART initiated before 6 months of age
Yes 0.027 2.86 1.12 7.25 0.860 0.86 0.16 4.63
No   1.00     1.00   
Use of ART >3 months
Yes a a a a a a a a
No   1.00       
Advanced clinical and immunological disease (B3C123)
Yes 0.003 4.41 1.68 11.61     
No   1.00       
Percentage CD4+ T-cell count
>25%   1.00     1.00   
15–24% 0.296 1.87 0.58 6.07 0.244 2.62 0.52 13.22
<15% 0.012 4.25 1.38 13.06 0.107 5.06 0.71 36.29
Baseline HIV viral load
≥ 100,000 0.004 6.42 1.84 22.36 0.115 3.31 0.75 14.71
<100,000   1.00     1.00   
Origin of diagnosis
Mother had AIDS when she became pregnant   1.00     1.00   
Mother during prenatal care a a a a a a a a
Mother during or following delivery, or father 0.017 0.12 0.02 0.69 0.108 0.13 0.01 1.57
When the child became ill 0.247 0.39 0.08 1.92 0.532 0.49 0.05 4.64
At diagnosis of a sibling a a a a a a a a
Comorbidities
P. jiroveci pneumonia 0.001 7.20 2.85 18.19 0.010 7.26 1.62 32.54
Thrombocytopenia 0.001 5.02 1.89 13.33     
Severe recurrent bacterial infections 0.003 4.27 1.61 11.32     
Candidiasis - any type 0.005 3.47 1.45 8.30     
Chronic anemia 0.012 6.73 1.53 29.64     
Hepatitis/ HIV 0.004 3.85 1.53 9.65     
Wasting syndrome 0.027 2.76 1.12 6.77     
Extrapulmonary cryptococcosis 0.040 12.87 1.12 147.70     
Kidney disorders 0.042 12.61 1.10 144.72 0.020 50.92 1.84 1411.87**
Tuberculosis 0.037 2.90 1.07 7.92     
Lymphadenopathy >0.5 cm at more than two sites 0.061 0.44 0.19 1.04     
Severe recurrent bacterial infection 0.082 2.51 0.89 7.05     
Prolonged diarrhea or gastroenteritis 0.099 2.05 0.87 4.84     
  1. a: not calculated, no cases.
  2. *Analysis performed with data from 153 cases (86.4% of the sample).
  3. **This value is high due to problems in calculating the confidence interval, since there were few cases of this variable.
  4. The numbers in boldface highlight the statistical significance.
  5. Infectious Diseases and AIDS Pediatric Care Clinic of the State Pediatric Hospital between 2001 and 2011 (n = 177), Vitoria, Brazil.