Figure 1
From: Th17 cytokine deficiency in patients with Aspergillus skull base osteomyelitis
SBO patients have an intact innate immune response, but are defective in IL-17 and IL-22 production. PBMCs stimulated with E. coli LPS, heat killed C. albicans yeast, S. aureus and A. fumigatus were cultured for 24 hours 48 hours or 7 days respectively. The innate cytokines IL-1β (A), TNFα (B), IL-6 (C) (after 24 hours) and adaptive cytokines IFNγ (D) (after 48 hours) and IL-17 (E) /IL-22 (F) (after 7 days) were measured in the cell culture supernatant by ELISA. Controls (black bars, n = 6) compared with SBO patients (white bars, n = 6).