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Table 2 Virologic responses of the different fibrosis groups

From: Interleukin-28B gene non-TT allele strongly predicts treatment failure for genotype 1 infected chronic hepatitis C patients with advanced fibrosis: a case control study

Response

Overall

Group A

Group B

 

HCV genotype

n/N (%)

n/N (%)

n/N (%)

p-value

RVR

102/151 (67.5)

21/36 (58.3)

81/115 (70.4)

0.176

 1

50/91 (54.9)

9/22 (40.9)

41/69 (59.4)

0.129

 Non-1

52/60 (86.7)

12/14 (85.7)

40/46 (87)

0.9.5

cEVR

140/154 (90.9)

30/37 (81.1)

110/117 (94)

0.017

 1

77/91 (84.6)

15/22 (68.2)

62/69 (89.9)

0.014

 Non-1

63/63 (100)

15/15 (100)

48/48 (100)

–

ETR

148/168 (88.1)

36/42 (85.7)

112/126 (88.9)

0.582

 1

84/100 (84)

21/25 (84)

63/75 (84)

1

 Non-1

64/68 (94.1)

15/17 (88.2)

49/51 (96.1)

0.234

SVR

98/168 (58.3)

19/42 (45.2)

79/126 (69.7)

0.047

 1

46/100 (46)

6/25 (24)*

40/75 (53.3)**

0.011

 Non-1

53/68 (76.5)

13/17 (76.5)*

39/51 (76.5)**

1.0

SVR (with RVR)

77/102 (75.5)

14/21 (66.7)

63/81 (77.8)

0.291

 1

35/50 (70)

4/9 (44.4)

31/41 (75.6)

0.065

 Non-1

42/52 (80.8)

10/12 (83.3)

32/40 (80)

0.797

Relapse

50/148 (33.8)

17/36 (47.2)

33/112 (29.5)

0.05

 1

38/84 (45.2)#

15/21 (71.4)

23/63 (36.5)

0.005

 Non-1

12/64 (18.8)#

2/15 (13.3)

10/49 (20.4)

0.539

Discontinuation

13/168 (7.7)

6/42 (14.3)

7/126 (5.6)

0.067

 1

8/100 (8)

3/25 (12)

5/75 (6.7)

0.395

 Non-1

5/68 (7.4)

3/17 (17.6)

2/51 (3.9)

0.06

  1. n, number of patients with response; N, total number of patients in the group.
  2. HCV, hepatitis C virus; RVR, rapid virologic response; cEVR, complete early virologic response; ETR, end of treatment response; SVR, sustained virologic response.
  3. Group A, patients with Ishak fibrosis score 4–6.
  4. Group B, patients with Ishak fibrosis score 0–3.
  5. *p = 0.001; **p = 0.008, #p = 0.001.