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Table 1 Serotype-specific Streptococcus pneumoniae Immunoglobulin G titres (IgG) in an adult with previously unknown hyposplenia suffering from recurrent episodes of invasive pneumococcal disease (IPD)

From: Recurrent severe invasive pneumococcal disease in an adult with previously unknown hyposplenia

IPD event, serotype Date Serotype,μg/ml #
   1 3 4 5 6B 7F 9V 12F MFI 14 17F MFI 18C 19A 19F 23F
1 st IPD, day 5, 7F 17.08.2008 0.91 0.09 0.20 <0.02 0.58 0.13 0.47 239.5 2.97 281,3 1.06 0.67 0.85 1.72
1 st IPD, day 20, 7F 02.09.2008 1.00 0.09 0.23 <0.02 0.59 0.17 0.50 250.3 2.73 295.5 0.86 0.77 1.55 1.75
2 nd IPD, day 16, 17F 29.07.2012 2.81 0.38 0.49 0.94 2.54 1.23 3.07 387.8 3.49 367.5 2.58 3.14 3.97 5.35
PCV13 immunization 13.09.2012 ** ** ** ** ** ** **   **   ** ** ** **
Post-immunization* 30.10.2012 5.62 0.57 0.21 0.41 6.02 0.42 5.02 n/a 33.24 n/a 12.32 1.99 2.67 2.48
3 rd IPD, day 3, 17F 06.01.2013 3.23 0.20 0.12 0.18 2.00 0.18 2.05 174.5 15.52 198.5 3.84 0.82 0.97 1.31
  1. #, Blood samples were analyzed for antigen-specific IgG-titers against 14 different pneumococcal serotypes measured by a Luminex xMAP microsphere-based liquid array modified from Pickering et al. [Pickering JW, Hill HR. Measurement of antibodies to pneumococcal polysaccharides with luminex xMAP microsphere-based liquid arrays. Methods Mol Biol. 2012;808:361–75]. The type-specific protective IgG-titers are unknown. Levels beneath 0.35 μg/ml are marked with bold as studies suggest that titers above 0.35 μg/ml provide protection against invasive pneumococcal disease after vaccination with a conjugated vaccine. IgG-titers are listed in μg/ml based on the 89SF international standard, except 12 F and 17 F, which are listed in mean fluorescence intensity (MFI) because a reference material were not available.
  2. *Average of two measurements on the same sample.
  3. **, Serotypes covered by the PCV13 vaccine.
  4. n/a, not available.