From: Prevalence and management of antibiotic associated diarrhea in general hospitals
Total sample of AB users n = 743 | Comparison between nonAAD and AAD patients | |||
---|---|---|---|---|
nonAAD n = 672 | AAD n = 71 | pvalue of difference | ||
Demographics characteristics | ||||
Age (yrs) mean (range) | 67.7 (16-99) | 67.3 (18.1) | 71.9 (16.8) | 0.040 |
Gender% male | 51.5% | 47.9% | 53.5% | 0.369 |
Clinical characteristics | ||||
Transfer from other ward | 16.5% | 16.4% | 16.9% | 0.917 |
ADL score (6-24) mean (SD) | 12.3 (5.7) | 12.0 (5.6) | 14.2 (5.8) | 0.002 |
Disorientation score (2-8) mean (SD) | 2.9 (1.7) | 2.9 (1.6) | 3.5 (1.9) | 0.001 |
Risk factors for diarrhea | ||||
Inflammatory bowel disease | 7.3% | 7.4% | 5.6% | 0.577 |
Proton pump inhibitors | 54.6% | 53.1% | 69.0% | 0.011 |
Chemotherapy | 6.2% | 6.0% | 8.5% | 0.406 |
Radiotherapy | 2.0% | 1.8% | 4.2% | 0.165 |
Tube feeding | 3.9% | 3.6% | 7.0% | 0.151 |
Endoscopic procedures | 15.9% | 14.9% | 25.4% | 0.022 |
Abdominal surgery | 3.1% | 2.8% | 5.6% | 0.194 |
Diabetes | 26.6% | 25.7% | 35.2% | 0.086 |
COPD | 25.4% | 25.7% | 22.5% | 0.555 |
HIV | 1.2% | 1.2% | 1.4% | 0.873 |
Transplantation | 3.0% | 3.0% | 2.8% | 0.940 |
Decubitus | 0.4% | 0.1% | 2.8% | 0.001 |
Laxatives | 15.8% | 16.4% | 10.9% | 0.260 |
Risk score (sum of factors) mean (SD) | 1.5 (1.1) | 1.5 (1.1) | 1.9 (1.1) | 0.001 |
Antibiotic use before diarrhea | ||||
More than one antibiotic prescribed | 19.2% | 18.0% | 31.0% | 0.008 |
Type of antibiotics* | ||||
Penicillins | 63.1% | 62.9% | 64.8% | 0.760 |
Quinolones | 22.2% | 21.6% | 28.2% | 0.204 |
Cephalosporins | 11.8% | 12.1% | 9.9% | 0.586 |
Macrolides | 8.1% | 8.2% | 7.0% | 0.737 |
Aminoglycosides | 3.4% | 3.6% | 1.4% | 0.336 |
Sulfonamides | 1.7% | 1.8% | 1.4% | 0.818 |
Other ab | 7.3% | 7.0% | 9.9% | 0.376 |