Figure 2

Phylogenetic analysis of N2 genes derived from 1,254 H3N2-positive samples taken from humans and N2 genes from 1,450 N2-positive (irrespective of hemagglutinin identity) avian samples. The sequences represent a randomly chosen subset of the total set of altogether 7,342 N2 sequences analyzed. All seven sequences containing the OE resistance mutation R292K are included in the dendrogram. N2 sequences derived from birds are indicated by red vertical bars, and N2 sequences from human samples are indicated by blue vertical bars. N2 sequences from bird samples that map in clusters of sequences from human samples are denoted by red arrows, whereas sequences from human samples in clusters of sequences from avian samples are denoted by blue arrows. Details for these sequences are given in the bottom right section of the figure. Sequences carrying an OE resistance mutation are indicated by black arrows. The two major clusters of sequences are indicated by block capitals A and B.