Demographic variables
| | | |
Annual maternal mortality rates
| | |
UNICEF [20]
|
<12 months ART
| | | |
>350 cells/mm3
|
3.3%
|
-
| |
200-350 cells/mm3
|
3.9%
|
-
| |
<200 cells/mm3
|
11.1%
|
-
| |
>12 months ART
| | | |
>350 cells/mm3
|
1.0%
|
-
| |
200-350 cells/mm3
|
1.1%
|
-
| |
<200 cells/mm3
|
1.8%
|
-
| |
Number of children
|
2.34
|
1-5
|
Chart review
|
Transition Probabilities
| | | |
Access to care
|
82%
|
50-95%
|
Ghana Health Service [7]
|
Adherence to ART
|
90%
|
50-95%
|
Ghana Health Service [7]
|
Transmission during pregnancy
| | | |
No therapy/non-adherence
|
22%
|
15-30%
|
Ghana Health Service [12]
|
Option B
|
10%Ϯ
|
0-15%
|
Ghana Health Service [12]
|
Option B-Plus
|
1%
|
0-5%
|
Ghana Health Service [12]
|
Transmission during breastfeeding
| | | |
No therapy/non-adherence
|
10%
|
5-20%
|
Ghana Health Service [12]
|
Option B
|
1%
|
0-5%
|
Ghana Health Service [12]
|
Option B+
|
1%
|
0-5%
|
Ghana Health Service [12]
|
Changes to CD4 Count
| | | |
No therapy (every 3 months)
|
−12.75 cells/mm3
|
5-20 cells/mm3
|
Holmes 2006 [15]
|
Initiate therapy
|
+153 cells/mm3
|
100-400 cells/mm3
|
Deeks 1999 [16]
|
Continue therapy (every 3 months)
| | | |
Previously interrupted therapy
|
−0.06365 × [Current CD4]
|
-
|
Ickovics et al. 2001 [14]
|
Continuous therapy
|
- 0.0099853 × [Current CD4]
|
-
|
Ickovics et al. 2001 [14]
|
Costs in USD [GHS]
| | | |
Annual Cost of HIV Care
| | | |
First-Line ART
|
385.45 [743.91]
|
191-580
|
WHO 2011 [17]; Rosen, J., and F. Asante. 2010 [18]
|
Second-Line ART
|
848.33 [1,637.28]
|
-
|
WHO 2011 [17]; Rosen, J., and F. Asante. 2010 [18]
|
Lifetime Cost of Care for HIV+ Child (including ART costs)
|
10,665.49 [20,584.40]
|
5,181-15,544
|
WHO 2011 [17]; Rosen, J., and F. Asante. 2010 [18]
|
Quality-of-life Factor
| | | |
HIV+ adult (quality of life)
|
0.8
|
0.50-1.0
|
Tengs T.O., Lin T.H. 2002 [19]
|
HIV+ child (lifetime QALYs)
|
20.2ϮϮ
|
10-30
|
UN Impact of AIDS 2004 [32]
|
HIV- child (lifetime QALYs)
|
62.7
|
50-70
|
UN Impact of AIDS 2004 [32]
|
Discount rate
|
0.03
|
0.00-0.05
|
Weinstein et al. 1996 [23]
|