Table 2 Treatment factors associated with reduced P. aeruginosa bacterial burden at END of PEx therapies
Factor | ALL | MUC | NON | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Value | OR (95% CI) | Value | OR (95% CI) | Value | OR (95% CI) | Value | OR (95% CI) | Value | OR (95% CI) | Value | OR (95% CI) | |
1-log reduction | 2-log reduction | 1-log reduction | 2-log reduction | 1-log reduction | 2-log reduction | |||||||
Antibiotics* | ||||||||||||
FEP vs other ABx | 7/22 vs 61/97 | 0.51 (0.27-0.95), p = 0.009 | 6/22 vs 49/97 | 0.54 (0.26-1.08), p = 0.06 | 13/20 vs 61/81 | 0.86 (0.61-1.22), p = 0.40 | 7/20 vs 49/81 | 0.57 (0.31-1.00), p = 0.05 | 9/21 vs 55/89 | 0.69 (0.41-1.16), p = 0.14 | 6/21 vs 45/89 | 0.56 (0.28-1.14), p = 0.08 |
CAZ vs other ABx | 36/56 vs 32/63 | 1.27 (0.93-1.73), p = 0.19 | 29/56 vs 26/63 | 1.25 (0.85-1.85), p = 0.27 | 36/49 vs 38/52 | 1.00 (0.8-1.27), p = 1.0 | 32/49 vs 24/52 | 1.41 (0.99-2.02), p = 0.08 | 34/50 vs 30/60, | 1.36 (0.99-1.86), p = 0.07 | 27/50 vs 24/60 | 1.35 (0.90-2.01, p = 0.18 |
Treatment parameters* | ||||||||||||
<14 vs ≥14 days | 32/68 vs 29/52 | 0.84 (0.6-1.2), p = 0.36 | 23/55 vs 38/65 | 0.7 (0.5-1.24), p = 0.09 | 38/74 vs 13/28 | 1.1 (0.7-1.74), p = 0.8 | 25/56 vs 26/46 | 0.78 (0.53-1.16),p = 0.3 | 30/64 vs 28/46 | 0.77 (0.54-1.1), p = 0.17 | 20/51 vs 38/59 | 0.6 (0.41-0.9), p = 0.01 |