From: Expression of inhibitory regulators of innate immunity in patients with active tuberculosis
Systemic host response | Local host response | ||
---|---|---|---|
Healthy controlsn = 29 | Primary TBn = 54 | All TB-positive bronchoscopy patientsn = 9 | |
Demographics | |||
Age (years) | 31 (26–35) | 28 (22–42) | 35 (24–48) |
Male sex (n, %) | 21 (72%) | 40 (74%) | 7 (78%) |
Smoker (n, %) | 8 (28%) | 27 (50%) | 5 (56%) |
HIV-positive (n, %) | 0 (0%) | 1 (2%) | 1 (11%) |
Symptoms | |||
Fever (n, %) | 0 (0%) | 54 (100%) | 9 (100%) |
Night sweats (n, %) | 0 (0%) | 21 (39%) | 1 (11%) |
Weight loss (n, %) | 0 (0%) | 39 (72%) | 4 (44%) |
Fatigue (n, %) | 1 (3%) | 29 (54%) | 4 (44%) |
Shortness of breath (n, %) | 0 (0%) | 6 (11%) | 0 (0%) |
Productive cough (n, %) | 2 (7%) | 50 (93%) | 8 (89%) |
Signs | |||
Temperature (°C) | 36.9 (36.5-37.1) | 37.4 (36.8-38.1)*** | 37.3 (36.5-38.3)* |
MAP (mmHg) | 83.3 (80–93.3) | 80 (70–87)** | 77 (73–82)** |
Heart rate (bpm) | 80 (78–84) | 90 (81–100)*** | 84 (80–105) |
Respiratory rate (brpm) | 20 (20–24) | 25 (24–28)*** | 20 (20–28) |
BMI (w/l2) | 24 (22.4-25.7) | 17.7 (15.6-19.6)*** | 18.3 (16.3-22.6)** |