Figure 1
From: Expression of inhibitory regulators of innate immunity in patients with active tuberculosis
ST2 during active pulmonary tuberculosis. (A) ST2 mRNA in PBMCs; (B) ST2 surface expression measured on CD4 and CD8 positive lymphocytes and CD14 positive monocytes (representative histograms). FMO, fluorescence minus one. (C) Idem for individual subjects (geomean channel fluorescence intensity (MFI)). (D) Plasma sST2 concentrations. (E) ST2 mRNA in alveolar macrophages (AM) of TB patients originating from the TB infected lung (open squares) or contralateral lung (closed squares). Depicted mRNA levels are normalized to the house keeping gene β2-microglobulin. Depicted are dot plots with medians; open dots: TB patients, closed dots: healthy donors. ***P < 0.001.