Skip to main content

Table 1 Fitted dose-response models for selected agents

From: Dose-response models for selected respiratory infectious agents: Bordetella pertussis, group a Streptococcus, rhinovirus and respiratory syncytial virus

     Exponential Model Beta-Poisson Model
Host Exposure (unit) Outcome Ref κ (95%CI) AICa p-valueb α, β (N50) AICa p-valueb
Bordetella pertussis
Mouse (10 day old) Intranasal (CFU) Infection [39] 1.14 × 10−8 607 0 0.086, 2000 50.9 0.431
(6.47 × 10−9, 3.73 × 10−8) (0.632)
Mouse (4 week old) Intranasal (CFU) Mortality [40] 6.28 × 10−8 58.9 0 0.239, 8.91 × 105 47.3 0.972
(4.85 × 10−8, 8.75 × 10−8) (51900)
Mouse (6 day old) Intranasal (CFU) Mortality [40] 3.83 × 10−5 158 0 0.556, 252 24.2 0
(1.52 × 10−5, 1.04 × 10−3) (102)
Mouse (21 day old) Aerosol (CFU inhaled) Mortality [41] 2.15 × 10−6 8.25 0 3.34, 1.19 × 106 10.0 0
(1.10 × 10−6, 5.76 × 10−6) (5.16 × 106)
Group A Streptococcus
Mouse Intranasal (CFU) Infection [46] 1.05 × 10−6 72.8 0.088 0.341, 1260 15.6 0.308
(3.19 × 10−7, 2.04 × 10−4) (5460)
Mouse Intranasal (CFU) Mortality [46] 1.38 × 10−6 9.22 0 0.762, 1.98 × 105 10.1 <0.001
(4.59 × 10−7, 7.44 × 10−6) (1.34 × 105)
Rhinovirus
Human Intranasal (TCID50) Infection [51] 1.00 11.4 0 0.725, 0.173 12.8 0
(0.484, 1.00) (0.108)
Human (antibody-free) Intranasal (TCID50) Infection [50] 0.366 75.2 0.009 0.701, 0.111 16.9 0.427
(0.125, 1.00) (0.066)
Human (antibody-free, pooled) Intranasal (TCID50) Infection [50,51] 0.428 89.9 0 0.697, 0.121 25.8 0
(0.154, 1.00) (0.071)
Human (antibody ≤ 4) Intranasal (TCID50) Infection [50] 0.138 123 0 0.374, 0.076 24.0 0.358
(0.074, 0.420) (0.014)
Respiratory Syncytial Virus
Human Intranasal (TCID50) Infection [55] 9.98 × 10−5 5.92 0.002 1.14, 6610 7.69 0.034
(2.41 × 10−5, 5.08 × 10−4) (7900)
Human (pooled) Intranasal (TCID50) Infection [54,55] 2.34 × 10−5 20.3 0.014 0.217, 1380 16.0 0.080
(1.18 × 10−5, 4.42 × 10−5) (59.0)
Human (pooled) Intranasal (TCID50) Infection [53-55] 2.86 × 10−5 95.5 0.572 0.026, 8.59 × 10−8 39.6 0.999
(1.65 × 10−5, 5.60 × 10−5) (2.27 × 10−19)
  1. aAIC is Akaike’s Information Criterion.
  2. bp-value is for the permutation test.