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Table 3 Etiologies of SARI in children < 5 years old, by age group, in Kibera, Nairobi, Kenya

From: Severe acute respiratory infection in children in a densely populated urban slum in Kenya, 2007–2011

 

<1 year n (%)

12-23 months n (%)

24-59 months n (%)

All cases, n (%)

Total patients seen

12445

11838

21385

45668

SARI cases

980 (7.9%)

718 (6.1%)

894 (4.2%)

2592 (5.7%)

Rate of SARI (per 100 PYO)

30.4

16.7

6.7

12.4

CFRa for SARI cases

13 (1.3%)

2 (0.3%)

3 (0.3%)

18 (0.7%)

Blood cultures (BC) done

270 (27.6%)

243 (33.8%)

349 (39.0%)

862 (33.3%)

BCs without contaminant

259 (26.4%)

236 (32.9%)

341 (38.1%)

836 (32.3%)

S. pneumoniae b

4 (1.5%)

3 (1.3%)

1 (0.3%)

8 (1%)

H. influenzae b

0

0

0

0

S. aureus b

10 (3.9%)

1 (0.4%)

3 (0.9%)

14 (1.7%)

Klebsiella pneumoniae b

0

0

0

0

Non-typhi Salmonellab

7 (2.7%)

3 (1.3%)

3 (0.9%)

13 (1.6%)

Salmonella Typhi

1 (0.4%)

2 (0.8%)

2 (0.6%)

5 (0.6%)

Other pathogenic bacteriab,c

0

0

1 (0.3%)

1 (0.1%)

Naso/oropharyngeal swabs collected

285 (29.1%)

241 (33.6%)

289 (32.3%)

815 (31.4%)

Influenza A

27 (9.4%)

26 (10.8%)

39 (13.5%)

92 (11.3%)

Influenza B

4 (1.4%)

6 (2.5%)

11 (3.8%)

21 (2.6%)

Influenza A or B

31 (10.9%)

31 (12.9%)

50 (17.1%)

112 (13.7%)

Respiratory syncytial virus

74 (25.9%)

49 (20.3%)

46 (15.8%)

169 (20.7%)

Adenovirus

57 (20%)

76 (31.5%)

108 (36.9%)

241 (29.5%)

Parainfluenza virus 1

10 (3.5%)

10 (4.1%)

8 (2.7%)

28 (3.4%)

Parainfluenza virus 2

7 (2.5%)

7 (2.9%)

11 (3.8%)

25 (3.1%)

Parainfluenza virus 3

31 (10.9%)

27 (11.2%)

19 (6.5%)

77 (9.4%)

Any Parainfluenza

46 (16.1%)

43 (17.8%)

34 (11.6%)

123 (15.0%)

Human metapneumovirus

39 (13.7%)

23 (9.5%)

35 (11.9%)

97 (11.9%)

Rhinovirus/Enterovirusd

32/76 (42%)

36/73 (49%)

29/55 (53%)

97/204 (47.5%)

Parechovirusd

3/76 (4%)

0

1/55 (1.8%)

4 (2.0%)

Atypical bacteriae

0

0

0

0

Positive > =1 virus

204 (71.6%)

182 (75.5%)

195 (66.8%)

581 (71.0%)

Positive > =2 virus

71 (24.9%)

67 (27.8%)

83 (28.4%)

221 (27.0%)

  1. All data presented as number and percentage in parentheses rounded to the nearest integer.
  2. aCase-fatality ratios (CFR) are defined as death in the 30 days following clinic visit for SARI episode.
  3. bDenominator = uncontaminated blood cultures from 836 patients. Blood culture results discarded if they contained coagulase-negative Staphylococcus, Bacillus species, or Corynebacteria.
  4. cOther pathogenic bacterium was Escherichia coli.
  5. dRhino/enterovirus, parechovirus, and atypical bacteria were only tested for from January 1, 2009 – February 28, 2010; 204 swabs were tested among persons <5 years old (76 specimens in <1 year olds, 73 on 12–23 month olds and 55 in 24–59 month olds).
  6. epresence of atypical bacteria (Mycoplasma pneumoniae, Chlamydophila pneumoniae, and Legionella species) was assessed by qPCR in 76 np/op swabs.
  7. March 1, 2007-February 28, 2011.