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Table 1 Characteristics of patients of cryptococcal meningoencephalitis

From: A retrospective study of contributing factors for prognosis and survival length of cryptococcal meningoencephalitis in Southern part of China (1998–2013)

Characteristic

Recovered [no. (%)] see

Dead [no. (%)]

Lost# [no. (%)]

Total

p#

Age, years

49(45.37)

45(41.67)

14(12.96)

108

NS

0-10

2(1.85)

1(0.93)

2(1.85)

5

 

11-20

7(6.48)

6(5.56)

2(1.85)

15

 

21-30

6(5.56)

9(8.33)

4(3.70)

19

 

31-40

13(12.04)

10(9.26)

2(1.85)

25

 

41-50

8(7.41)

8(7.41)

2(1.85)

18

 

51-60

10(9.26)

3(2.78)

1(0.93)

14

 

61-70

2(1.85)

3(2.78)

1(0.93)

6

 

71-80

1(0.93)

4(3.70)

0(0)

5

 

81-

0(0)

1(0.93)

0(0)

1

 

Gender

49(45.37)

45(41.67)

14(12.96)

108

NS

Male

36(33.33)

30(27.78)

11(10.19)

77

 

Female

13(12.04)

15(13.89)

3(2.78)

31

 

Time interval from illness onset to hospitalization (days)

49(45.37)

45(41.67)

14(12.96)

108

NS

1-10

9(8.33)

6(5.56)

1(0.93)

15

 

11-20

10(9.26)

13(12.04)

3(2.78)

25

 

21-30

13(12.04)

18(16.67)

5(4.63)

36

 

31-

17(15.74)

8(7.41)

5(4.63)

29

 

Underlying disease *

22(20.37)

21(19.44)

4(3.70)

47

NS

Exposure history

2(1.85)

3(2.78)

0(0)

5

NS

Brain tissue damaged **

9(8.33)

18(16.67)

4(3.70)

31

0.021

Laboratory findings

     

High intracranial pressure

43(39.81)

35(32.41)

13(12.04)

91

NS

Increased CSF protein

38(35.19)

31(28.70)

10(9.26)

79

NS

Decreased CSF glucose

26(24.07)

29(26.85)

9(8.33)

64

NS

Abnormal EEG ***

16(42.11)

9(23.68)

2(5.26)

27

NS

Abnormal MRI ****

20(41.67)

10(20.83)

4(8.33)

34

NS

  1. *Underlying diseases included use of corticosteroids or other immunosuppressants 19 cases, SLE 8 cases, Tuberculosis 6 cases (1 with CNS infection and 5 with lung infection), hematopathy 5 cases (2 with ITP, 1 with leukemia, 1 with NHL and 1 with AIHA), DM 5 cases, kidney diseases 4 cases (2 with renal failure, 1 with nephrotic syndrome and 1 with RPGN), HIV 2 cases, organ (renal) transplantation 1 case, cancer (nasopharyngeal carcinoma) 1 case, hyperthyroidism 1 case, pregnant 1 case, hepatitis B 1 case and mycotic infection 1 case.
  2. **Brain tissue damage included altered consciousness 17 cases, seizures 6 cases, cerebellum symptoms 6 cases and mental disorders 4 cases. (Several cases with more than one symptom).
  3. ***Abnormal EEG included normal background 20 cases (1 with epileptiform discharge and 19 with focal slow wave) and diffused slow wave in the background 7 cases.
  4. ****Abnormal MRI included Bubble sign 9 cases (6 at the basal ganglion and 3 at subcortex), hydrocephalus 16 cases, abnormal lesions 16 cases (8 cases with hemilateral lesions, 8 cases with bilateral lesions) and ischemic lesions 3 cases (2 with ischemic lesion and 1 with transient ischemic attack) (most cases with more than one abnormal features).
  5. #NS, not significant (p > 0.05).