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Table 1 Characteristics of randomized controlled trials included in the review

From: Effectiveness of topical corticosteroids in addition to antiviral therapy in the management of recurrent herpes labialis: a systematic review and meta-analysis

Study Setting Participants (n) Groups (n) Male, n (%) Frequency of RHL (mean episodes/year)
Hull et al. 2010 [18] 51 sites in the United States and 4 sites in Canada (July 2006 to December 2007) 1443 Intervention 406 (28) 5.6
1. ME-609 cream (5% Acyclovir, 1% Hydrocortisone) (n = 601)
Control
1. Acyclovir (5% in ME-609 vehicle) (n = 610)
2. Placebo (vehicle) (n = 232)
Evans et al. 2002 [19] 4 major university clinics in North America 380 Intervention 76 (20) 5.3
1. ME-609 cream (5% Acyclovir, 1% Hydrocortisone) (n = 190)
Control
1. Placebo (n = 190)
Hull et al. 2009 [20] University of Utah (August 2004 to March 2007) 39 Intervention 13 (33) 4.5
1. Oral Valacyclovir (2 g 2×/day for 1 day) plus topical Clobetasol gel (0.05% 2×/day for 3 days) (n = 20)
Control
1. Placebo (n = 19)
Spruance et al. 2000 [21] University of Utah Health Sciences Center, Salt Lake City 29 Intervention 14 (29) 5
1. Oral Famciclovir (Famvir, 500 mg 3×/day for 5 days) plus topical Fluocinonide (0.05% Lidex Gel 3×/day for 5 days) (n = 17)
Control
1. Famciclovir and topical vehicle control (n = 12)