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Table 4 Clinical outcomes and resource use

From: Early response to antibiotic treatment in European patients hospitalized with complicated skin and soft tissue infections: analysis of the REACH study

 

Definition 1

Definition 2

Clinical outcomes and resource use

Early responders

Not-early responders

Early responders

Not-early responders

n = 363

n = 237

n = 417

n = 173

Initial treatment modification, n (%)

124 (34.2)

114 (48.1)

148 (35.5)

87 (50.3)

Overall treatment duration, days, mean (SD) [median]

10.8 (8.7) [9.0]

17.6 (15.3) [13.0]

11.3 (10.2) [9.0]

18.4 (14.7) [14.0]

Length of hospital stay, days, mean (SD) [median]

14.3 (16.7) [9.0]

22.8 (24.5) [16.0]

14.8 (17.3) [10.0]

24.3 (25.7) [18.0]

Surgery after diagnosis, n (%)

98 (27.0)

91 (38.4)

121 (29.0)

63 (36.4)

Reinfection or recurrence, n (%)

29 (8.0)

24 (10.1)

34 (8.2)

16 (9.2)

Admitted to ICU, n (%)

15 (4.1)

38 (16.0)

27 (6.5)

26 (15.0)

Time in ICU, days, mean (SD) [median]

4.4 (4.6) [3.5]

10.1 (15.3) [5.0]

6.6 (9.7) [4.0]

10.4 (16.4) [5.0]

Acute renal failure, n (%)

2 (0.6)

14 (5.9)

4 (1.0)

12 (6.9)

Length of acute renal failure, days, mean (SD) [median]

3.5 (2.1) [3.5]

20.5 (54.2) [4.0]

3.0 (1.7) [2.0]

22.0 (56.3) [4.5]

Blood pressure support, n (%)

    

Fluid resuscitation

20 (5.5)

36 (15.2)

27 (6.5)

28 (16.2)

Vasopressors

3 (0.8)

22 (9.3)

6 (1.4)

19 (11.0)

Invasive procedures

0

0

0

0

Septic shock, n (%)

3 (0.8)

15 (6.3)

6 (1.4)

12 (6.9)

Isolation required, n (%)

7 (1.9)

18 (7.6)

13 (3.1)

11 (6.4)

Parenteral nutrition, n (%)

9 (2.5)

16 (6.8)

11 (2.6)

13 (7.5)

Length of parenteral nutrition, days, mean (SD) [median]

10.7 (10.2) [6.0]

38.4 (71.3) [12.0]

11.6 (11.3) [6.0]

43.9 (77.8) [13.0]

Home-based care after discharge, n (%)

45 (12.4)

31 (13.1)

54 (12.9)

20 (11.6)

Mortality, n (%)

5 (1.4)

9 (3.8)

6 (1.4)

8 (4.6)

  1. ICU = Intensive care unit.