Definition 1 | Definition 2 | |||
---|---|---|---|---|
Clinical outcomes and resource use | Early responders | Not-early responders | Early responders | Not-early responders |
n = 363 | n = 237 | n = 417 | n = 173 | |
Initial treatment modification, n (%) | 124 (34.2) | 114 (48.1) | 148 (35.5) | 87 (50.3) |
Overall treatment duration, days, mean (SD) [median] | 10.8 (8.7) [9.0] | 17.6 (15.3) [13.0] | 11.3 (10.2) [9.0] | 18.4 (14.7) [14.0] |
Length of hospital stay, days, mean (SD) [median] | 14.3 (16.7) [9.0] | 22.8 (24.5) [16.0] | 14.8 (17.3) [10.0] | 24.3 (25.7) [18.0] |
Surgery after diagnosis, n (%) | 98 (27.0) | 91 (38.4) | 121 (29.0) | 63 (36.4) |
Reinfection or recurrence, n (%) | 29 (8.0) | 24 (10.1) | 34 (8.2) | 16 (9.2) |
Admitted to ICU, n (%) | 15 (4.1) | 38 (16.0) | 27 (6.5) | 26 (15.0) |
Time in ICU, days, mean (SD) [median] | 4.4 (4.6) [3.5] | 10.1 (15.3) [5.0] | 6.6 (9.7) [4.0] | 10.4 (16.4) [5.0] |
Acute renal failure, n (%) | 2 (0.6) | 14 (5.9) | 4 (1.0) | 12 (6.9) |
Length of acute renal failure, days, mean (SD) [median] | 3.5 (2.1) [3.5] | 20.5 (54.2) [4.0] | 3.0 (1.7) [2.0] | 22.0 (56.3) [4.5] |
Blood pressure support, n (%) | ||||
Fluid resuscitation | 20 (5.5) | 36 (15.2) | 27 (6.5) | 28 (16.2) |
Vasopressors | 3 (0.8) | 22 (9.3) | 6 (1.4) | 19 (11.0) |
Invasive procedures | 0 | 0 | 0 | 0 |
Septic shock, n (%) | 3 (0.8) | 15 (6.3) | 6 (1.4) | 12 (6.9) |
Isolation required, n (%) | 7 (1.9) | 18 (7.6) | 13 (3.1) | 11 (6.4) |
Parenteral nutrition, n (%) | 9 (2.5) | 16 (6.8) | 11 (2.6) | 13 (7.5) |
Length of parenteral nutrition, days, mean (SD) [median] | 10.7 (10.2) [6.0] | 38.4 (71.3) [12.0] | 11.6 (11.3) [6.0] | 43.9 (77.8) [13.0] |
Home-based care after discharge, n (%) | 45 (12.4) | 31 (13.1) | 54 (12.9) | 20 (11.6) |
Mortality, n (%) | 5 (1.4) | 9 (3.8) | 6 (1.4) | 8 (4.6) |